葡甲酸环腺苷酸对老年冠心病充血性心力衰竭患者校正QT离散度的影响  

Influence of meglumine cyclic adenylate (MCA) on QTcd in patients with congestive heart failure secondary coronary heart diseases

作　　者：刘翠中[1] 刘湘华[1] 杨晓春[1] 

机构地区：[1]湖南省人民医院老干部科,410002

出　　处：《国外医学（心血管疾病分册）》2002年第2期109-111,共3页

摘　　要：目的:探讨葡甲酸环腺苷酸治疗对冠心病充血性心力衰竭患者QTcd的影响。方法:将80例冠心病充血性心力衰竭患者随机分为葡甲酸环腺苷酸治疗组和非葡甲酸环腺苷酸治疗组。观察分析了80例冠心病充血性心力衰竭患者葡甲酸环腺苷酸治疗前后QTc max、QTc min、QTcd,的变化。结果:与治疗前比较,两组心衰患者治疗后QTc max、QTcd均有减少,差异有显著性(P<0.01),以葡甲酸环腺苷酸治疗组减少更明显。治疗后两组间QTc max、QTcd差异有显著性(P<0.01)。结论:葡甲酸环腺苷酸可通过缩短QTc max而减少冠心病心衰患者的QTcd。Objective: To investgate the effect of MCA on the corrected QT dispersion (QTcd) in patients with congestive heart failure due to coronary heart diseases. Methods: 80 patients were devided into 2 groups; MCA treatment group (conventional treatment + MCA) and conventional treatment group. The changes of QTc max, QTc min, QTcd were measured before and after treatment. Results: Both QTc max and QTcd were decreased significantly in two groups after 10 days of treatment(P<0.01), but it decreased more significantly in MCA treatment group than in conventional group. there were significant differences in QTc max and QTcd of two groups after treatment(P<0.01). Conclusions: By shortening QTc max,MCA can diminish the QTcd of patients with congestive heart disease due to coronary heart diseases.

关 键 词：冠心病 充血性心力衰竭 QT离散度 葡甲酸环腺苷酸 老年人 

分 类 号：R541.6[医药卫生—心血管疾病]