金粉蕨素对小白鼠实验性肝损伤脂质过氧化的保护作用  

Protective Effect of Onychin on Lipid Peroxidation in Experimental Liver Damage of Mice

作　　者：严奉祥[1] 朱炳阳[1] 郑兴[1] 胡剑峰[2] 葛晓莉 黄红林[1] 廖端芳[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001 [2]南华大学

出　　处：《南华大学学报（医学版）》2002年第1期4-6,共3页Journal of Nanhua University(Medical Edition)

基　　金：国家卫生部课题 (98- 1- 345 );湖南省教委课题 (98B10C)

摘　　要：目的　探索金粉蕨素对脂质过氧化保护作用。方法　取昆明种小白鼠 48只 ,随机分成 6组 ,分别给予溶媒、维生素E和不同剂量的金粉蕨素 ,然后采用溴代苯所致实验性肝损伤 ,再用TBA测定肝匀浆的丙二醛 (MDA)含量。结果　不同剂量的金粉蕨素均可明显降低肝匀浆脂质过氧化产物MDA的含量 (P <0 .0 1 ) ,其中 ,低和中剂量组的MDA含量较高剂量组低。结论　金粉蕨素具有较好的抗氧化作用 ,对脂质过氧化损伤具有一定的保护作用。Objective: To investigate the protective effect of Onychin on lipid peroxide in mice. Methods: 48 mice were randomly divided into 6 groups.Vehicle, Vitamin E and different dose of Onychin were given respectively, and then experimental injury of mice liver was induced to make use of bromobenzene and the content of MDA was determined in liver homogenate. Results: Different dose of Onychin significantly decrease the content of lipid peroxide MDA in liver homogenate (P< 0.01). Among them, low and middle dose of Onychin showed a stronger effect on lowing MDA than high dose of Onychin. Conclusion: Onychin possesses anti-oxidation and protective effect from liver damage induced by lipid peroxide.

关 键 词：小白鼠 脂质过氧化 保护作用 金粉蕨素 溴代苯 肝损伤 抗氧化 丙二醛 药理 

分 类 号：R285.5[医药卫生—中药学]