海珠益肝胶囊对小鼠免疫性肝损伤的影响  

Effect of Haizhuyigan Capsule on the Hepatic Damage of Immunity in Mice

作　　者：李卫星[1] 谭大琦[1] 李秋华[1] 刘桂喜[1] 姜楠[1] 洪文[1] 竺稽能[1] 

机构地区：[1]湖北中医学院附属医院,430061

出　　处：《中西医结合肝病杂志》2002年第2期99-100,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:进一步证实海珠益肝胶囊对肝损伤小鼠的保肝降酶作用。方法:来用卡介苗+脂多糖(BCG+LPS)造成免疫性肝损伤模型小鼠,观察本品对血清中ALT、AST活力单位、肝脾脏器系数和肝脏病理组织学损伤程度的影响。结果:药物能降低血清中ALT、AST活力单位(P<0.01);减小肝脾肿大及脏器系数(P<0.01);减轻肝组织病理损伤程度。结论:海珠益肝胶囊对BCG+LPS所致肝损伤小鼠有明显保肝降酶作用。Objective: It is evidenced further that Haizhuyigan (HZYG) capsule can protect liver and drop ALT and AST active unite in mice. Method: The model of hepatic damage of immunity by BCG+LPS. Effects of HZYG capsule were observed on ALT and AST active unite in serum, the coefficient of liver and spleen, dimension of hepatic damage in the histopathology. Results:HZYG capsule could drop ALT and AST active unite in serum (P<0. 01) (decrease coefficient of liver and spleen (P<0.01) s reduce dimension of hepatic damage in the histopathology. Conclusion: HZYG capsule can protect the liver from immune damage induced by BCG+LPS in mice.

关 键 词：海珠益肝胶囊 卡介苗 脂多糖 免疫性肝损伤 小鼠 中药 药理 

分 类 号：R285[医药卫生—中药学]