含钆造影剂在动脉血管造影和介入治疗中的初步应用  

Gadopentetate dimeglumine as contrast agent for arteriography and interventional radiologic procedures: preliminary application

作　　者：王仲朴[1] 王茂强[2] 孙永光[1] 刘晓君[1] 

机构地区：[1]北京海淀医院放射科,100080 [2]解放军总医院

出　　处：《介入放射学杂志》2002年第2期97-101,共5页Journal of Interventional Radiology

摘　　要：目的　研究含钆造影剂在动脉血管造影和介入治疗中应用的可行性。方法　 9例接受血管造影诊断及介入治疗的患者 ,2例有使用碘剂的禁忌证而单纯使用含钆造影剂 ,7例同时进行了含碘与含钆造影剂比较。造影血管包括胸主动脉、颈总动脉、支气管动脉、肋间动脉、肝动脉、髂动脉及子宫动脉。含钆造影剂为离子型钆喷替酸葡甲胺 ,使用剂量≤ 0 .3mmol/kg体重。术中监护生命体征及血氧饱和度 ,术后进行血尿常规和肝肾功能检查。结果　 7例患者进行含碘与含钆造影剂血管造影图像质量比较 ,含钆造影剂在显示动脉主干血管影像与含碘造影剂无显著性差异 ,远端分支及肿瘤染色的图像质量差于含碘造影剂。 2例患者单纯使用含钆造影剂完成血管造影及介入治疗。含钆造影剂动脉内注射对患者肝肾功能无不良影响 ,对慢性肾功能不全患者无不良影响。结论　应用含钆造影剂做DSA可获得较清晰的图像 ,对于碘剂过敏或慢性肾功能不全患者可应用含钆造影剂进行动脉血管造影。Objective To investigate the feasibility of gadopentetate dimeglumine as contrast agent for arteriography and interventional procedures.Methods Nine patients received gadopentetate dimeglumine as contrast agent during interventional procedures. Gadopentetate dimeglumine was used in 2 patients with contraindications to iodinated contrast media. In addition to the standard injection sequences with iodinated contrast media, arteriograms were obtained after administration of gadopentate dimeglumine in seven patients. Diagnostic arteriographies were performed in thoracic aorta, common carotid artery, bronchial artery, intercostal artery, hepatic artery, iliac artery and uterine artery. The doses of gadopentetate dimeglumine used in this series were≤0.3 mmol/kg. Vital signs and arterial oxygen saturation were monitored during the procedures. The blood and urine routine examinations, the hepatic and renal functions tests were done after the procedure. Results There were no significant differences between the gadopentetate dimeglumine and the iodinated contrast media examinations for illustrating the main trunk of these arteries. Angiograms obtained with the iodinated contrast media appeared to be better than that of with gadopentetate dimeglumine for visualizing the distal branches of these arteries and the tumor stain. The interventional procedure was completed successfully in the two patients using gadopentetate dimeglumine alone. No patient suffered from complication related to the use of gadopentetate dimeglumine, and also no worsened renal function was shown after the procedure. Conclusions Diagnostic arteriograms can be achieved safely and successfully by using gadopentetate dimeglumine, especially in patients with allergy to iodinated contrast media and chronic renal insufficiency.

关 键 词：含钆造影剂 动脉血管造影 造影剂 血管造影术 介入放射学 

分 类 号：R815[医药卫生—放射医学]