肾炎合剂治疗慢性肾炎的临床研究  

Clinical Study of Chronic Nephritis Treated with Mixture-Glomerulonephritis

作　　者：万晨旭[1] 别晓东[2] 王钢[3] 

机构地区：[1]南京中医药大学,南京210029 [2]浙江大学医学院附属第二医院 [3]江苏省中医院全国中医肾病医疗中心

出　　处：《中国中医药信息杂志》2002年第4期13-15,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的:观察肾炎合剂治疗慢性肾炎(CGN)的疗效,探讨其作用机埋。方法:将50例CGN患者按抽签法随机分为西药组和中药组,分别给予维生素E O.2/d、肾炎合剂50ml/d,分2次口服。1个月为一疗程,治疗2个疗程。观察近期疗效、治疗后患者症状、尿蛋白、内生肌酐清除率(Ccr)及血清中超氧化物歧化酶(SOD)、脂质过氧化终产物丙二醛(MDA)含量的变化情况。结果:治疗后两组总有效率、尿蛋白定量、Ccr、SOD活性相比均有显著差异(P<0.05),两组治疗后症状积分相比有非常显著差异(P<0.01),但两组治疗后MDA相比无显著差异(P>0.05)。结论:肾炎合剂能显著改善患者的临床症状,明显减少尿蛋白以保护肾脏,提高Ccr以改善肾功能;其作用机理在于能较好地抗氧自由基(OFR)损伤,从而达到治疗CGN气阴两虚证之目的,且具有较好的疗效。Objective:To investigate the effect and mechanism of Mixtrue-glomerulenephritis (MGRN) on chronic nephritis. Methed:50 patients of chronic nephritis were divided into 2 groups at random. The experimental group was treated with MGRN as compared with Vitmin E acetate, which was served as control. Both before and after treatment, the symptom, urine protein、Ccr、SOD、MDA of patients were test respectly. Result:There were significant differences between MGRN group and Vitamin E group on symptom (P<0.01). While there was no significant difference on MDA (P>0.05). Conclusion:MGRN can improve the clinical symptoms of patients in chronic nephritis, decrease urine protein to defect nephron, improve the patients’Ccr, eliminate the lesion of oxydant, to cure the patients of deficiency in qi and yin.

关 键 词：肾炎合剂 慢性肾炎 氧自由基 中医药疗法 治疗 

分 类 号：R277.523[医药卫生—中医学]