树脂法分离纯化米洛培南  

THE SEPARATION AND PURIFICATION OF MILUPEINAN BY ADSORPTION RESIN

作　　者：杨秀云[1] 印寿根[1] 张政朴[1] 郭红 张广明 

机构地区：[1]南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津3000712 [2]深圳太太药业集团研究所,深圳518057

出　　处：《离子交换与吸附》2002年第2期132-137,共6页Ion Exchange and Adsorption

摘　　要：采用国产AAS大孔吸附树脂及D-280大孔脱色树脂对抗生素米洛培南制备母液进行分离纯化。实验表明,与日本Diaion公司生产的Diaion CHP 20相比,AAS大孔吸附树脂对米洛培南具有更优良的吸附性能,使用D-280大孔脱色树脂对抗生素米洛培南制备母液进行脱色,未发现类似报道。分析结果证实,以上述方法制备的抗生素米洛培南收率高、纯度高,各项分析数据与文献报道相符。Adsorption resin AAS has been used for the separation and purification of milupeinan (M-13) from its mother liquor. The good adsorption property of AAS adsorption resin was found for milupeinan (M-13) compared with the Diaion CHP 20p. When acetone and water (2:1 in volume) were used as desorption reagents, it was found that 3 times of bed volume of the desorption reagents could completely desorb the saturately adsorbed M-13 on AAS. Also macroporous strong basic anion exchange resin (Poly-4-vinylpyridine type) D-280 was used for the decolourization from M-13 solution. The good results were given when the sv=1~2

关 键 词：AAS 大孔吸附树脂 D-280 大孔脱色树脂 米澡培南 分离 纯化 抗生素 

分 类 号：TQ465[化学工程—制药化工] TQ028.33