九配位钬-三乙四胺六乙酸配合物K_(3)[Ho(TTHA)]·5H_(2)O的合成及分子结构  

Synthesis and Molecular Structure of Nine-Coordinate Complex K_(3)[Ho(TTHA)]·5H_(2)O

作　　者：王君[1] 领小[1] 张向东[1] 贾卫国[1] 范大民[1] 

机构地区：[1]辽宁大学化学系,沈阳110036

出　　处：《无机化学学报》2002年第5期509-512,共4页Chinese Journal of Inorganic Chemistry

基　　金：辽宁省科委自然科学基金资助项目(No.9810300901)。

摘　　要：In this paper, the molecular and crystal structures of the K3·5H2O(TTHA=triethylenetetraminehexaacetic acid)are given. The crystal data are as follows: monoclinic system, P21/c space group, a=1.0290(9)nm, b=1.2466(11)nm, c=2.279(2)nm, β=91.322(16)°, V=2.923(5)nm3, Z=4, M=860.67, Dc=1.956gcm-3, μ=3.217mm-1, F(000)=1720. The final R1 and wR2 are 0.0395 and 0.0796 for 5145 [I >2.0σ(I)] unique reflections and 0.0546 and 0.0833 for all 11567 reflections, respectively. In the title complex, the anion 3- has a nine coordination structure with distorted tricapped trigonal prism. A TTHA having four N atoms of amido groups and six O atoms of carboxylic groups acts as a enneadentate ligand with four N atoms and five O atoms. In addition, there is a free non coordinated carboxyl group ( CH2COO-) in the complex anion 3-. The free carboxyl group could be embellished by some biological molecules which have selectivity and affinity to tumor cell. Then the 166HoⅢ TTHA complex may become radioactive anti tumor drug having targeting function.In this paper, the molecular and crystal structures of the K3·5H2O(TTHA=triethylenetetraminehexaacetic acid)are given. The crystal data are as follows: monoclinic system, P21/c space group, a=1.0290(9)nm, b=1.2466(11)nm, c=2.279(2)nm, β=91.322(16)°, V=2.923(5)nm3, Z=4, M=860.67, Dc=1.956gcm-3, μ=3.217mm-1, F(000)=1720. The final R1 and wR2 are 0.0395 and 0.0796 for 5145 [I >2.0σ(I)] unique reflections and 0.0546 and 0.0833 for all 11567 reflections, respectively. In the title complex, the anion 3- has a nine coordination structure with distorted tricapped trigonal prism. A TTHA having four N atoms of amido groups and six O atoms of carboxylic groups acts as a enneadentate ligand with four N atoms and five O atoms. In addition, there is a free non coordinated carboxyl group ( CH2COO-) in the complex anion 3-. The free carboxyl group could be embellished by some biological molecules which have selectivity and affinity to tumor cell. Then the 166HoⅢ TTHA complex may become radioactive anti tumor drug having targeting function.

关 键 词：Ho(Ⅲ) 三乙四胺六乙酸 配合物 分子结构 合成 

分 类 号：O614.343[理学—无机化学]