女性寻常性痤疮患者免疫球蛋白补体及可溶性IL-2R的检测  

Investigation on Serum Immunoglobulin Complements and sIL-2R in Female Patients with Acne Vulgaris

作　　者：王建琴[1] 曾仁山[1] 唐韶生[1] 杨捷[1] 吴江[1] 贝春花[1] 

机构地区：[1]广州市第一人民医院皮肤科,广东广州510180

出　　处：《中国皮肤性病学杂志》2002年第2期79-81,共3页The Chinese Journal of Dermatovenereology

基　　金：广州市医药卫生科研课题 (960 3)

摘　　要：目的　探讨女性寻常性痤疮患者细胞及体液免疫功能状况。方法　采用速率散射比浊法测定 5 8例女性寻常性痤疮患者免疫球蛋白IgG、IgA、IgM及补体C3 、C4 ;采用ELISA双抗体夹心法测定 5 8例女性寻常性痤疮患者血清可溶性白细胞介素 2受体 (sIL 2R)水平 ;同时以 30例正常女性作为对照。结果　患者组免疫球蛋白IgG、IgA、IgM及补体C3 、C4 无明显变化 ;但痤疮严重程度不同 ,IgG的变化差异有显著性 (P <0 .0 0 1) ,其余指标差异无显著性。Ⅰ度组IgG明显低于正常对照组 (P <0 .0 1) ;Ⅱ度组与正常对照差异无显著性 (P >0 .0 5 ) ;Ⅲ度组较正常对照明显升高 (P <0 .0 0 1)。痤疮越严重 ,IgG越高 ,Ⅱ度组显著高于Ⅰ度组 (P <0 .0 5 ) ,Ⅲ度组显著高于Ⅱ度组 (P <0 .0 0 1)。血清sIL 2R水平明显高于正常人对照 (P <0 .0 0 1)。结论　免疫反应参与了痤疮的发病过程 ,免疫应答涉及到体液免疫及细胞免疫两个途径。Objective To investige the functions of humoral and cell-mediated immunity in female patients with acne vulgaris.Methods The serum immunoglobulin IgG,IgM,IgA and complements of C 3 and C 4 were measured with Rate-nephelometry in 58 female cases with acne vulgaris.A sandwich ELISA technique was applied to detect serum levels of sIL-2R in 58 female patients with acne vulgaris compared with that of 30 healthy control subjects at the same time.Results The results revealed that the serum Immunoglobulin IgG,IgM,IgA and complements of C 3 and C 4 in 58 female cases with acne vulgaris showed no significantl differences between patients and control subjects(P>0.05).But there were different results in different groups,the changes of IgG had significant differences(P<0.001),the others haden't great changes(P>0.05).Compared with that of control subjects,IgG were significantly lower in acne Ⅰ (light degree group,P<0.01) and were significantly higher in acne Ⅲ(severity degree group,P<0.001),no differences in acne Ⅱ(middle degree group,P>0.05).The more severity of acne,the higher IgG.IgG in acne Ⅱ were significantly higher than that in acne Ⅰ(P<0.05).IgG in acne Ⅲ were significantly higher than that in acne Ⅱ(P<0.001).The levels of sIL-2R in patients(1878.24±677.46pg/ml) were significantly higher than those in the control subjects(1215.90±354.06pg/ml)(P<0.001).Conclusion The immunity reaction takes part in the pathogenesis of acne.The immunologic response involves both humoral and cell-mediated pathways.

关 键 词：寻常性痤疮 免疫球蛋白 补体 可溶性 白细胞介素2 受体 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]