针刺对多因素AD模型海马ChE活性影响的实验研究  

Effects of acupuncture on hipporampi cholinesterase of multifactorial AD model.

作　　者：董洪涛[1] 白英[2] 

机构地区：[1]南京中医药大学,现调广西中医药学院210029 [2]南京脑科医院,210029

出　　处：《实用老年医学》2002年第2期85-87,共3页Practical Geriatrics

基　　金：江苏省教育厅高校科研基金项目 ;基金号为KJB360 0 0 5

摘　　要：目的　本研究模拟建立一个集衰老、铝中毒与胆碱能系统损害的多因素老年性痴呆 (AD)动物模型 ,并验证针刺的作用效果。　 方法　以西药哈伯因作对照 ,检测各模型组以及治疗组海马胆碱酯酶 (ChE)活性 ,研究针刺对这种模型ChE活性的影响。　 结果　发现在D 半乳糖亚急性衰老的基础上的单纯铝中毒模型和单纯东莨菪碱 (SCOP)模型均显示出了类似AD的海马ChE活性表现 ,多因素方法较之单因素方法有更明显的神经生化改变。　 结论　本研究提示这种多因素损伤方法可以更好地模拟出AD的病因、病理机制特征 ,并首次证明针刺有提高多因素AD模型动物海马ChE活性的作用 ,为针刺治疗AD的有效性提供了进一步的实验依据。Objective To improve the method of inducing AD model in rats,we tried to rebuild a multifactorial animal AD model,and exam the effect of acupuncture in treating AD. Methods we prepared 7 groups of rats,compared with Huperzine A,through the inspecting for hippocampi cholinesterase (ChE)activity to exam the effects of acupuncture on the model. Results the model rats which were given D galactose,scopolamine and aluminum toxicosis showed decreased hippocampi ChE activity.The result indicated that multifactorial AD model could get more obvious neurobiochemical disorders than simple factor model. Conclusions The multiple factor damaging AD model may be one of the methods of preparing dementia model of rats with learning and memory disorders.For the first time it was affirmed that acupuncture could improve hippocampi ChE activity,which offered the experimental proof for the efficacy of acupuncture in treating AD.

关 键 词：老年性痴呆 针刺疗法 胆碱脂酶 哈伯因 

分 类 号：R277.791.6[医药卫生—中医学] R332