泛议衰老  

The discussion of senescence

作　　者：黄燕[1] 赵寿元[1] 

机构地区：[1]复旦大学遗传学研究所,上海200433

出　　处：《生命科学》2002年第2期65-69,共5页Chinese Bulletin of Life Sciences

摘　　要：衰老是机体在退化时期功能下降及生理紊乱的综合表现，与机体的自由基水平、染色体端粒长度和衰老过程中起作用的重要基因有密切关系。作者重点介绍自由基学说、饮食限制学说、端粒学说，以及衰老相关基因 WRN、klotho和胰岛素样生长因子1 （IGF-1）的信号传导途径，从遗传学的角度对衰老机理作一阐述。Senescence is the syndrome about the function decline and physiological disorder duringthe organism deterioration. Free redical levels, telomere length and some genes are closely relatedto senescence. Free-redical theory, caloric restriction theory and telomere theory are the keytheories summarized in this article; WRN gene, klotho gene and the signal transduction of IGF-1pathway related to senescence are also summarized. This paper illustrates the genetic backgroundof the mechanism of senescence.

关 键 词：衰老相关基因 自由基 端粒 饮食限制 信号传导 

分 类 号：R339.38[医药卫生—人体生理学] Q344.5[医药卫生—基础医学]