Delta-诱眠肽的研究进展  

A Review of Delta-Sleep-Inducing Peptide

作　　者：周闯[1] 田桂玲[1] 叶蕴华[1] 

机构地区：[1]生物有机与分子工程教育部重点实验室

出　　处：《高等学校化学学报》2002年第4期610-616,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:29872002)资助.

摘　　要：Ｄｅｌｔａ－诱眠肽是第一个已阐明化学结构的睡眠物质．本文评述了近２０年来用溶液法、固相法、酶促法及基因工程法合成Ｄｅｌｔａ－诱眠肽的研究进展．介绍了Ｄｅｌｔａ－诱眠肽的新生物活性及临床应用前景．概述了Ｄｅｌｔａ－诱眠肽的构效关系及溶液构象的研究进展,展望了Ｄｅｌｔａ－诱眠肽的研究方向．Delta sleep-inducing peptide (DSIP) was the first sleep-factor whose chemical structure hasbeen identified. Synthesis of DSIP by means of various methods, such as solution method, solid phasemethod, enzymatic promotion method and genetic engineering method, was discussed. Some new biologi-cal activities other than the somnogenic effect of DSIP were introduced. The structure-activity relationship(SAR) of DSIP and con formational study of this peptide in solution were also presented. Some approachesof further studies on DSIP were suggested.

关 键 词：Delta-诱眠肽 合成 生物活性 构效关系 多肽药物 临床应用 睡眠物质 溶液构象 

分 类 号：R977.6[医药卫生—药品] R971[医药卫生—药学]