卵巢早衰与自然绝经妇女骨密度比较及替勃隆疗效观察  

The difference of BMD between premature ovarian failure and natural menopausal women and the efficacy of tibolone

作　　者：王莉[1] 胡玮[1] 孔德诚[1] 白人骁[1] 

机构地区：[1]天津医院骨科研究所,天津300211

出　　处：《中国临床康复》2002年第7期988-988,998,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的比较卵巢早衰(POF)与自然绝经妇女的骨密度(BMD),并观察替勃隆的疗效。方法63例经DEXA确诊为骨质疏松的病人分为3组:29例POF为A组,年龄48～76(62.1±7.0)岁;34例自然绝经妇女为B组,年龄52～77(63.4±6.0)岁;63例中的32例应用替勃隆治疗(1.25mg/d,疗程6个月)为C组。应用美国Hologic公司QDR4500-W型双能X线骨密度仪测定A组和B组腰椎及股骨颈BMD,测定C组治疗前后的BMD。结果A、B两组L2～4、股骨颈BMD相比,有显著性差异(P<0.05);C组治疗前后L2～4、股骨颈BMD相比有非常显著性差异(P<0.01),平均增长率分别为2.7%、2.2%。结论POF比自然绝经妇女骨量丢失的早并且丢失的多,绝经后骨质疏松应用激素替代疗法效果明显。Objective To investigate the differences of bone mineral density (BMD) between premature ovarian failure (POF) and natural menopausal women and observe the results of treatment with tibolone.Methods Sixty three cases of diagnosed by osteoporosis were divided into three groups: 29 cases of POF were group A with the age of 48-76(62±7.0); 34 cases of natural menopausal were group B with the age of 52-77 (63.4±6.0);32 out of 63 cases were treated by tibolone(LivialTM 1.25mg/d for 6 months) as group C.The dual energy X ray absorptiometry (Hologic, QDR 4500 W) was used to determine the BMD of lumbar vertebrae and femoral neck in group A and group B and determine the BMD before and after treatment in group C.Results There were significant differences of BMD of L 2-4 and femoral neck between group A and group B (P< 0.05).The BMD before and after treatment had significant differences in group C (P< 0.01) and the average rate of increase was 2.7% and 2.2% respectively.Conclusion The bone loss of POF is early and more than that of natural menopausal women. The BMD of postmenopausal women are increased obviously by treating with tibolone.

关 键 词：绝经后 骨质疏松 卵巢早衰 骨密度 替勃隆 激素替代疗法 

分 类 号：R681[医药卫生—骨科学] R711.75[医药卫生—外科学]