持续低热致深度烧伤的实验观察  

An experimental investigation of deep burn by constant low heat

作　　者：马文元[1] 霍成[1] 田社民[1] 曹平[1] 

机构地区：[1]郑州市第一人民医院烧伤科,450001

出　　处：《中华烧伤杂志》2002年第2期99-101,共3页Chinese Journal of Burns

摘　　要：目的　研制持续低热烧伤动物模型 ,观察基本规律并探讨其机制。　方法　 (1)将大鼠按不同温度及时相点随机分组 ,背部持续接触热源 ,观察创面形成过程、全层皮肤密度及病理变化。(2 )将温度计置于大鼠背部皮肤筋膜下 ,观察不同时间和温度下 ,大鼠皮下温度的变化。　结果　 (1)随温度上升 ,创面形成时间明显缩短 ,损伤程度逐渐加重。大鼠皮肤密度的变化 ,在不同时间表现为不规则双曲线或三曲线。 (2 )稳定实验条件后 ,各组大鼠皮下温度的变化呈抛物线状。　结论　 (1)持续接触低热 ,皮下温度的快速增高及由此造成的变性、坏死是导致深度烧伤的原发因素。 (2 )皮肤组织损伤的变化规律是热源损伤、毛细血管通透性增加、组织重量变化等多重作用的结果。Objective To investigate the basic p athogenetic rule and mechanism of deep burn by constant low heat. Methods Animal burn model inflicted by constant low heat was est ablished as follows. (1) The rats were randomly divided into groups in terms of temperature and duration of contact. The burn wound formation process, the skin tissue density and pathomorphological changes in the rats were observed after bu rn was produced on the back by contacting heat source constantly. (2) The subcut aneous temperature of the back was monitored at different time and temperatures of heat contacting by placing the thermometer under the fascia of the rat back. Results (1) The time of burn wound formation was shortened and t he injury degree deepened along with the increase in the contact temperature.The rat skin density exhibited irregular hyperbola or triple curves.(2) The subcuta neous temperature exhibited a parabolic curve with fixed experimental conditions . Conclusion (1) The sharp increase in subcutaneous temperature l eading to degeneration and necrosis might be the primary cause of deep burn. (2) The regularity of the skin tissue injury was the result of multiple effects of heat origin injury, increase of capillary permeability and the change in tissue mass.

关 键 词：皮肤温度 病理过程 持续低热 动物模型 深度烧伤 

分 类 号：R644[医药卫生—外科学]