发病6小时内急性心肌梗死溶栓患者肌钙蛋白T观察  

Deletion of Serum Cardiac Troponin T on Patients with Acute Myocardial Infarction after Venous Thrombolytic Therapy

作　　者：张楠[1] 王大通[1] 熊为国[1] 逯春鹏[1] 姜荣生[1] 

机构地区：[1]北京酒仙桥医院,北京100016

出　　处：《中国医药导刊》2002年第2期122-123,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:评价肌钙蛋白T(TnT)反映心肌损伤的高敏感性及其对心肌再灌注的判断价值。方法:对87例发病6h内的急性心肌梗死(AMI)静脉溶栓患者的心肌酶CK、CK-MB及心肌TnT进行监测,其中TnT测定采用电化学发光免疫分析技术。结果:1.CK、CK-MB及TnT开始升高的时间无显著差异(P>0.05);2.初始升高的相对浓度TnT明显高于CK(P<0.01)及CK-MB(P<0.001);3溶栓4h内TnT及CK-MB上升速度再通组明显大于未通组(前者P<0.001,后者P<0.01),且TnT与CK-MB上升速度有显著差异(再通组P<0.001,未通组P<0.05)。结论:TnT为反映心肌损伤的高敏感血清标志物,溶栓4h内TnT及CK-MB上升速度可作为临床判断溶栓疗效的参考指标,且TnT优于CK-MB。Objective: To explore sensitivity of serum cardiac troponin T (cTnT) on judgement of myocardiol injury and clinical significance of cTnT on evaluation of reperfusion on patients with acute myocardial infarction (AMI) after venous thrombolytic therapy. Method: This study was designed to detect CK.CK - MB and cTnT of 87 patients with AMI within 6 hours after venous thrombolytic therapy. TnT was measured by electrochemiluminescence(ECL) analytical technology. Results: There was no significant difference in the original rising time between CK.CK - MB and TnT of patients with AMI by statistical level(P > 0.05) ; Within 4 hours after thrombolytic therapy and the increase in TnT and CK - MB concentration in patients after thrombolytic therapy, the increase speed of TnT and CK - MB concentration in patients with reperfused AMI was significantly faster than that of non - reper-fused AmI (P < 0.001, P<0.01); The relative rising concentration in TnT at beginning was greater than that of CK (P < 0.01) and CK - MB (P < 0.001) respectively. Conclusions: TnT had high sensivity on judgement of myocardiol injury. The rising speed of cTnT and CK - MB , especially TnT , at first 4 hours after venous thrombolytic therapy in patients with AMI may be a clinical parameter for judgement of reperfusion.

关 键 词：急性心肌梗死 静脉溶栓 肌钙蛋白T 心肌损伤标志物 诊断 

分 类 号：R542.22[医药卫生—心血管疾病]