电刺激束旁核、中央中核对猫丘脑后核群内脏痛放电的影响  

Effects of Electrically Stimulating Parafascicular Nucleus andCentromedian Nucleus on Visceral Pain Discharges inPosterior Group of Thalamic Nuclei in Cat

作　　者：符文双[1] 吴敏范[1] 张新刚[2] 张桦[3] 

机构地区：[1]沈阳医学院医学基础部生理学教研室,辽宁沈阳110034 [2]中国医科大学研究生处 [3]中国医科大学脑研究所神经生理研究室

出　　处：《沈阳医学院学报》2002年第1期16-18,共3页Journal of Shenyang Medical College

摘　　要：目的:研究束旁核、中央中核在痛觉调制中的作用及作用机理。方法:以电刺激内脏大神经在丘脑后核群诱发的单位放电作为内脏痛指标,应用细胞外玻璃微电极记录技术及条件-检验刺激技术。结果:束旁核、中央中核对丘脑后核群内脏痛放电主要表现为抑制作用,抑制作用形式可分为即时抑制、延迟抑制及持续抑制。纳洛酮可拮抗中央中核的抑制作用。结论:束旁核、中央中核参与内脏痛的调制,主要为抑制内脏痛;内源性阿片样物质参与中央中核对该内脏痛的抑制过程。ve:To research the effects of parafascicular nucleus(PF)and centromedian nucleus (CM) on visceral pain discharges, and their mechanisms. Methods: As an index of visceral pain, the discharges of the neurons in the posterior group of thalamic nuclei ( PO), evoked by stimulating greater splanchnic nerve (GSN) in 41 cats, were investigated extracellularly. The effects of PF and CM on the unit discharges were studied with test-conditioning stimulation techniques. Results:After stimulating PF or CM (conditioning stimulus ) electrically, the neuron discharges in PO, caused by excitation of GSN (test stimulus) , were mainly depressed. The patterns of inhibitory action of PF or CM can be classified into three kinds: prompt inhibition, delayed and continued ones. These inhibitions of CM were antagonized by Naloxone. Conclusion:PF and CM were involved in regulation of visceral pain, mainly in analgesia of visceral pain in our experiments. Endogenous opiate-like substances were involved in the CM-induced inhibitory process.

关 键 词：痛觉 内脏痛 纳洛酮 束旁核 中央中核 丘脑后核群 内脏大神经 镇痛 生理学 

分 类 号：R339.11[医药卫生—人体生理学]