枸橼酸莫沙必利片治疗功能性消化不良的临床研究  

Effect of mosapride citrate on functional dyspepsia

作　　者：李兆申[1] 邹多武[1] 许国铭[1] 叶萍[1] 张梅勤[1] 李珍[2] 

机构地区：[1]第二军医大学长海医院消化内科,上海200433 [2]长海医院药学部

出　　处：《第二军医大学学报》2002年第4期387-390,共4页Academic Journal of Second Military Medical University

基　　金：上海市卫生系统百人计划基金资助项目(98BR026);上海市青年科技启明星计划资助项目(99QB14045).

摘　　要：目的：评价枸椽酸莫沙必利对功能性消化不良（FD）的疗效及安全性。方法：60例FD患者随机分为两组，治疗组予以枸椽酸莫沙必利5mg，3次/d，治疗4周；对照组予以西沙必利5mg，3次/d，治疗4周。治疗前存在胃排空延迟患者，治疗后用不透X线小钡条法复查固体食物胃排空。结果：莫沙必利及西沙必利治疗4周均可显著改善FD患者早饱、上腹胀、上腹痛、暧气、反酸及烧心感等症状（与治疗前比P＜0．01）；莫沙必利对上述症状的有效率分别为59．09％、55．56％、81．82％、71．43％、100％及76．92％，西沙必利有效率分别为45．45％、73．33％、71．43％、82．61％、92．86％及66．67％，两组比较无显著差异（P＞0．05）。莫沙必利及西沙必利均可改善胃排空延迟患者胃排空率，前者对胃排空改善的有效率为88．24％，后者为83．33％，两组比较无显著差异（P＞0．05）。两组患者治疗后均无 QTC间期延长等不良反应。结论：枸椽酸莫沙必利是治疗 FD安全、有效的药物。Objective: To investigate the effect of mosapride citrate on functional dyspepsia (FD). Methods: Sixty pa-tients with FD were randomized into 2 groups. Five mg mosapride citrate was given 3 times daily to the medical group, and 5mg cisapride 3 times daily to the control group for 4 weeks. At the end of the medication, gastric emptying of solid food withradiopaque markers was carried out in patients with delayed gastric emptying at the beginning. Results: Both mosapride andcisapride significantly improved the symptoms of early satiety, abdominal distention, abdominal pain, belching, regurgitationand heartburn in patients with FD (P＜0. 01). The effective rate of mosapride on the above symptoms were 59. 09%,55. 56%, 81. 82%, 71. 43%, 100% and 76. 92% respectively, which had no significant difference to that of cisapride(45. 45%, 73. 33%, 71. 43%, 82. 61%, 92. 86% and 66. 67%, respectively). Besides, mosapride and cisapride improvedgastric emptying rate in patients with delayed gastric emptying,the effective rate were 88. 24% and 83.33%, respectively.There were no side effects or prolongation of QTC intervals in 2 groups. Conclusion: Mosapride citrate is an effective andsafe medicine in the treatment of FD.

关 键 词：功能性消化不良 莫沙必利 西沙必利 临床试验 FD 疗效 安全性 

分 类 号：R975.1[医药卫生—药品] R57[医药卫生—药学]