莫达非尼的合成  

Synthesis of Modafinil

作　　者：窦清玉[1] 伍新燕[1] 吴范宏[1] 

机构地区：[1]华东理工大学化学与制药学院,上海200237

出　　处：《中国医药工业杂志》2002年第3期110-111,共2页Chinese Journal of Pharmaceuticals

摘　　要：Modafinil, a new central stimulant, was synthesized from diphenylmethanol and 2-mercaptoacetic acid by a four-step reaction: condensation, chlorination, amination and then oxidation, in an overall yield of 58%.Modafinil, a new central stimulant, was synthesized from diphenylmethanol and 2-mercaptoacetic acid by a four-step reaction: condensation, chlorination, amination and then oxidation, in an overall yield of 58%.

关 键 词：莫达非尼 合成 合成路线 

分 类 号：TQ463.26[化学工程—制药化工]