新N_4型酒石酸酰胺配体的合成、标记及其生物分布研究  

PREPARATION OF LABELLED SMALL NOVEL N_4 LIGANDS TECHNETIUM-99m COMPLEXES FOR IMAGING AGENTS AND BIODISTRIBUTION IN MICE

作　　者：张华北[1] 齐传民[1] 冯淑娟[1] 付立民[1] 黄晓斌[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《北京师范大学学报（自然科学版）》2002年第2期240-244,共5页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金资助项目 (2 980 10 0 2 ;2 0 1710 0 8)

摘　　要：以L(+ ) 酒石酸为原料 ,设计、合成了R ,R构型的 2种N4 型配体以及99mTc的配合物 ,它们均为光化学纯结构 ,化合物通过了IR ,1HNMR ,13 CNMR及元素分析的测试 .进行了99mTc的标记 ,动物实验结果表明 ,2个目标物的99mTc标记配合物在小鼠肾中有较高的初始摄取量 ,尤其是N ,N 二乙基酒石酸二乙二胺99mTc 配合物不仅有较高的肾摄取 ,且有较长的滞留时间 ,肾与血的活度比高 ,有望发展成为一种新的肾功能显像剂 .Two new target chelators are synthesized through different active diamine with L (+) tartaric acid, 2,3 dihydrary succinic acid as primitive materials, all of which are identified on the basis of the spectroscopic data, such as IR, 1HNMR, 13 CNMR, and elementary analysis. All the chelators are labeled with technetium 99m and further tested for the biological activity in mice. The bio distribution results in mice indicate that 99m Tc B has high kidney uptake, good retention, quick blood clearance and high activity ratios of kidneys to other tissues, suggesting that it will be a new potential renal function imaging agent.

关 键 词：新N4型酒石酸酰胺配体 显像剂 ^99mTc放射性标记 生物分布 肾功能显像剂 

分 类 号：R981[医药卫生—药品] R817.4[医药卫生—药学]