婴儿乙型肝炎疫苗3剂标准程序免疫失败者再免疫后的抗体应答  

Response to Additional Doses in Infants Who Were Non-responsive after Vaccination with a Standard Three-dose Hepatitis B Vaccine Schedule

作　　者：张英林 刘洪斌[2] 马景臣 孟宗达[2] 韩常全 刘玉忠 赵卉 张玉伟 邢占春 张领梅 

机构地区：[1]正定县卫生防疫站,河北正定050800 [2]河北省疾病预防控制中心,石家庄050021

出　　处：《中国计划免疫》2002年第2期69-70,共2页Chinese Journal of Vaccines and Immunization

基　　金：国家"九五"医学科技攻关项目 (96-90 6-0 3 -0 2 )

摘　　要：为了解婴儿按 0、1、6个月程序接种 3剂乙型肝炎 (乙肝 )疫苗后 ,对抗体应答低下者实施再免疫后的乙肝病毒表面抗体 (抗 -HBs)阳转状况 ,在正定县 7个乡选取 1997年 1月 1日～ 1998年 8月 31日出生的婴儿 ,按 0、1、6个月程序实施 3剂乙肝疫苗免疫 ,于 1999年 5月采血检测抗 -HBs、乙肝病毒表面抗原 (HBsAg)和乙肝病毒核心抗体 (抗 -HBc) ,对 3项指标均阴性的 90例又接种了 1～ 2剂乙肝疫苗 ,2剂间隔 1个月 ,分别在每剂接种 1个月后采血检测抗 -HBs。结果显示 :再免疫 1剂乙肝疫苗后 1个月抗 -HBs阳转率为 85 6 % (S/N≥ 2 1)和 6 5 6 % (S/N≥10 0 )。对再免疫 1剂后仍无抗体应答者中的 8例又接种了第 2剂乙肝疫苗 ,经 1个月检测抗 -HBs全部阳转 ,其中 4例抗体S/N值≥ 10 0 ;同时对再免疫 1剂后抗 -HBs弱阳性 (S/N值 2 1～ 9 9)者中的 15例又接种了第 2剂乙肝疫苗 ,经 1个月后检测仅 4例抗 -HBsS/N值≥ 10 0 ,占 2 6 7%。因此 ,对按 3剂标准程序接种乙肝疫苗后免疫失败者再接种疫苗 ,可以诱导抗 -HBs阳转。Ninety non-responsive inf ants after a standard three-dose h epatitis B(HB)vaccine at 0,1,6 mon ths schedule were enrolled to rece ive an additional 1～2 doses of HB vaccine One month after the first dose,the anti-HBs positive seroconvers ion rates were 85 6% for S/N≥2 1 and 65 6% for S/N≥10 0 ,8 non-responsive infants when given second dose of HB vaccine, all positively anti-HBs seroconverted at l month later, in 4 of them anti-HBs reached S/N≥10 0. 15 infants who were weakly responded (S/N2 1～9 9),when receiving second dose in 4 of them developed positive anti-HBs,S/N≥10 0 one month later accounting for 26 7% Through this study,we found that positive anti-HBs sercoversion in non-responsive infants could be induced by additional HB vaccine doses

关 键 词：乙型肝炎疫苗 免疫应答 再免疫 抗-HBS阳转率 婴儿 

分 类 号：R512.62[医药卫生—内科学] R186[医药卫生—临床医学]