核黄素注射液光和热降解动力学的研究  

STUDIES ON PHOTO-AND THERMAL-DEGRADATION KINETICS OF RIBOFLAVIN INJECTION

作　　者：钟术光[1] 詹先成[1] 李琳丽[1] 李成蓉[1] 林涛[1] 易涛[1] 何宁[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2002年第2期90-91,94,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目 (批准号 :39770 882 )

摘　　要：目的　研究核黄素注射液光和热降解动力学的规律。方法　采用恒温加热与光照试验方法。结果　核黄素注射液在光和热共同作用下的反应速率方程为 :-dc/dt =(kheat+klight)c,其中 ,kheat=Aheatexp(-Eaheat/RT) ,klight=Alight·exp(-Ealight/RT)·E。结论　Ealight的数值与光源的种类无关。OBJECTIVE To study the photo-and thermal-degradation kinetics of riboflavin injection. METHODS Isothermal heating and exposure to lamplight were employed in the experiments.RESULTS The degradation of riboflavin injection obeys the first order kinetics on exposure to light at high temperature: -dc/dt=(k heat+k light)c, where k heat=A heat·exp(-Ea heat/RT) and k light=A light·exp(-Ea light/RT)·E.CONCLUSION The Ea light is independent of light sources.

关 键 词：光降解反应 热降解反应 动力学 研究 核黄素注射液 

分 类 号：R977.22[医药卫生—药品] R912[医药卫生—药学]