葛根异黄酮降低雌性去势大鼠血胆固醇水平  

Hypocholesterolemic Effect of Total Isoflavones from Pueraria lobata in Ovariectomized Rats

作　　者：郑高利[1] 张信岳[2] 郑经伟[2] 龚维桂[2] 郑筱祥[1] 陈安莉[1] 

机构地区：[1]浙江大学生物医学工程与仪器科学学院 [2]浙江省医学科学院药物研究所,杭州310013

出　　处：《中药材》2002年第4期273-275,共3页Journal of Chinese Medicinal Materials

基　　金：浙江省自然科学基金(No:399037);浙江省医药卫生优秀青年科技人才专项科研基金

摘　　要：目的:研究葛根异黄酮对雌激素缺乏大鼠脂质代谢的影响。方法:10月龄雌性SD大鼠手术切除双侧卵巢后1周口服葛根异黄酮,连续7个月,在第1.5、4.0和7.0个月时测定血清或肝脏的脂质水平。结果:双侧卵巢切除后大鼠血清TC水平明显上升,TC和HDL-C比值明显提高,TG水平无明显改变。口服葛根异黄酮使血清TC水平明显下降,HDL-C水平略有下降,二者的比值显著降低,血清TG水平在1.5月时明显下降,4.0和7.0无明显影响。肝脏甘油三酯水平显著降低,胆固醇水平有轻微的增加趋势。结论:葛根异黄酮降低去卵巢大鼠血清TC和肝脏甘油三酯水平。Objective:To observe the effects of total isoflavones from Pueraria labata (TIP) on lipid metabolism in estrogen deficient rat. Methods: Female SD rats were bilaterally ovariectomized under anesthesia. TIP was administrated orally for 7 months.Serum lipids were determined at 1.5,4.0 and 7.0 months,and liver lipids were detected at 7 months. Results: Compared with non-ovariectomized rats,serum TC level and the ration of TC/HDL-C in ovariectomized rats were obviously increased while HLD-C was slightly induced and TG level were changeless. In TIP-treated groups,serum TC level and the ratios of TC/HDL-C were markedly lowered than those in OVX group,while HDL-C slightly increased. TG level were much reduced in 1.5 month and changeless in 4.0 and 7.0 month. Slightly increase of cholesterol and markedly induction of triglyceride tissue were observed in liver. Conclusion: TIP significantly decreased concentrations of serum TC and liver TG in OVX rats.

关 键 词：雌激素 胆固醇 甘油三酯 葛根异黄酮 去势大鼠 

分 类 号：R285.5[医药卫生—中药学]