厄贝沙坦治疗轻、中度高血压病  

Irbesartan in treatment of mild to moderate essential hypertension

作　　者：蔡思宇[1] 张雪华[1] 胡晓晟[2] 吕兴广[1] 单江[1] 

机构地区：[1]浙江大学医学院附属第二医院心内科,浙江杭州310009 [2]浙江大学医学院附属第一医院心内科,浙江杭州310006

出　　处：《中国新药与临床杂志》2002年第5期277-280,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评价厄贝沙坦治疗轻、中度高血压病的临床疗效和安全性。方法 :选取轻、中度高血压病病人 ,采用双盲双模拟、随机对照法 ,比较厄贝沙坦与氯沙坦的降压效果。经 2wk安慰剂导入期后 ,服厄贝沙坦 (5 8例 ) 75mg ,qd或氯沙坦 (5 9例 ) 5 0mg ,qd ,于wk 4末坐位舒张压≥ 12kPa者则剂量加倍 ,继续服用 4wk。厄贝沙坦组 17例病人与氯沙坦组 14例病人 ,分别于治疗前及治疗wk 8末行 2 4h动态血压监测。结果 :8wk治疗末 ,有效率厄贝沙坦组 83%、氯沙坦组 78% ,2组比较差异无显著意义 (P >0 .0 5 )。厄贝沙坦的谷 /峰值收缩压为 81% ,舒张压为 70 % ,氯沙坦分别为 75 % ,71%。 2组最常见的不良反应是头晕。结论 :对轻、中度高血压病 ,厄贝沙坦是一种有效。AIM: To evaluate the efficacy and safety of domestic irbesartan in treating essential hypertension. METHODS: Forty patients(M 32,F 8; age 49 a± s 10 a) with mild to moderate essential hypertension were divided randomly into irbesartan group ( n =20)and valsartan group ( n =20). They received irbesartan 150 mg, po , qd or valsartan 80 mg, po , qd in a double blind randomized parallel design. The doses were remained or increased to 300 mg, po,qd or 160 mg,po,qd after 2 wk treatment depending on the blood pressure. The total cause of treatment was 4 wk. RESULTS: At the end of 4 wk treatment with irbesartan, the total effective rate was 75 % , the systolic pressure decreased (2.7± 1.8) kPa, the diastolic pressure decreased (1.3± 0.8) kPa.The rate of adverse reaction was 5 %. CONCLUSION:The domestic irbesartan is obviously effective for mild to moderate essential hypertension in short treating period. Administration once per day will keep long and stable efficiency.

关 键 词：厄贝沙坦 治疗 高血压 药物疗法 降压药 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]