经静脉注射腺苷终止阵发性室上性心动过速  

Intravenous adenosine in termination of paroxysmal supraventricular tachycardia

作　　者：蒋雄京[1] 张澍[1] 郎玫瑰[1] 冼颖 王虹剑[1] 王方正[1] 

机构地区：[1]中国医学科学院,中国协和医科大学阜外心血管病医院心内科,北京100037

出　　处：《中国新药与临床杂志》2002年第5期308-310,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评估经静脉注射腺苷终止室上性心动过速 (室上速 )发作的疗效及安全性。方法 :有阵发性心动过速病史且体表心电图提示室上速的病人2 2例 ,经静脉序贯冲击给药 ,依次予腺苷 3,6 ,12 ,18mg ,直至室上速终止。所有病例在完成研究后 1wk内进行心内电生理检查 ,排除 2例非阵发性室上速的病人。结果 :腺苷递增给药 3,6 ,12 ,18mg中 ,累积成功率分别达 2 5 % ,6 5 % ,85 % ,95 %。副作用发生率累计达 30 % ,多不严重 ,为一过性 ,在停止给药后 2min内消失。结论 :腺苷经静脉序贯冲击给药可快速有效地终止阵发性室上速。该药重复性好。副作用常见 。AIM: To assess the safety and efficacy of intravenous adenosine in terminating acute episodes of paroxysmal supraventricular tachycardia. METHODS: Twenty-two consecutive hospitalized patients with a tachycardia electrocardiographically consistent with paroxysmal supraventricular tachycardia, received sequential intravenous adenosine of 3, 6, 12, and 18 mg until the termination of supraventricular tachycardia. The patients underwent electrophysiology within 1 wk after the study ended. The two patients without AVRT or AVNRT were excluded from the efficacy analysis. RESULTS: The intravenous adenosine successfully terminated acute episodes of paroxysmal supraventricular tachycardia in 25 %, 65 %, 85 %, and 95 % of patients who received maximum doses of 3, 6, 12, and 18 mg, respectively, in a four dose sequence. The repeatability is excellent. Adenosine caused adverse reactions in 30 % of patients, but they lasted less than 2 min and were usually mild or moderate. CONCLUSION: Intravenous adenosine in graded doses rapidly and effectively terminates acute episodes of paroxysmal supraventricular tachycardia. Adverse reactions to adenosine are common but mostly tolerable.

关 键 词：经静脉注射 腺苷 阵发性室上性心运过速 药物疗法 治疗 

分 类 号：R541.71[医药卫生—心血管疾病] R972.2[医药卫生—内科学]