寻常型银屑病与单纯疱疹病毒1型相关性的研究  

Study on Association of Psoriasis Vulgaris with Herpes Simplex Virus Type1

作　　者：王官清[1] 张理涛[1] 徐宏慧[1] 李远宏[1] 王雅坤[1] 高兴华[1] 赵玉铭[1] 何春涤[1] 陈洪铎[1] 

机构地区：[1]中国医科大学第一临床学院皮肤科

出　　处：《中华皮肤科杂志》2002年第2期102-104,共3页Chinese Journal of Dermatology

摘　　要：目的探讨寻常型银屑病与单纯疱疹病毒1型(HSV-1)的可能相关性。方法应用PCR法检测患者皮损、外周血单一核细胞(PBMCs)和咽拭子中HSV-1DNA,ELISA法检测患者血清中抗HSV-1的IgM、IgG抗体,并与正常人对照做比较。结果患者皮损、PBMCs和咽拭子中HSV-1DNA检出率分别为37.5%、18.6%和18.8%,血清中抗HSV-1的IgM、IgG抗体检出率分别为37.2%和53.5%。经χ2检验,患者皮损、PBMCs中HSV-1DNA和血清中IgM抗体检出率显著高于正常人对照,点滴状患者的皮损、PBMCs和咽拭子中HSV-1DNA以及血清中抗HSV-1IgM抗体检出率显著高于斑块状患者。结论寻常型银屑病尤其是皮损呈点滴状者与HSV-1显著相关,患者可能存在HSV-1的近期感染。Objective To analyze the possible association of psoriasis vulgaris with herpes simplex virus type 1 (HSV-1). Methods Polymerase chain reaction was used to detect HSV-1 DNA in lesional skin biopsies, periphery blood mononuclear cells (PBMCs)and throat swabs from patients with psoriasis vulgaris, and ELISA was used to detect IgM and IgG antibodies against HSV-1 in sera from these patients. Results The positive detection rates of HSV 1 DNA in lesional skin biopsies, PBMCs and throat swabs were 37.5%, 18.6%and 18.8%, respectively. Anti HSV 1 IgM and IgG antibodies were positive in 37.2%and 53.5%of serum specimens, respectively. The detection rates of HSV 1 DNA in lesional skin biopsies and PBMCs, and IgM antibody in sera were significantly higher than those in normal controls. In psoriatic patients of guttate type the positive detection rates of HSV 1 DNA and IgM antibody were significantly higher than those in the plaque type. Conclusions There is strong association of psoriasis vulgaris, especially the guttate type, with HSV 1, and there may be recent infection of HSV 1 in these patients.

关 键 词：寻常型银屑病 单纯疱疹病毒1型 聚合酶链反应 酶联免疫吸附法 慢性炎症性皮肤病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R752.11[医药卫生—临床医学]