原发性肾病综合征血、尿内皮素和一氧化氮的变化及相互关系  

Change of plasma and urinary endothelin and nitric oxide in the children with primary nephritic syndrome and their relationship.

作　　者：康国贵[1] 骆纯才[1] 郭立申[1] 丁薇莎[1] 康友群[1] 

机构地区：[1]宁波市妇女儿童医院

出　　处：《华中医学杂志》2002年第2期77-78,共2页Central China Medical Journal

摘　　要：目的　探讨内皮素 (ET)、一氧化氮 (NO)在小儿原发性肾病综合征 (PNS)中的变化及相互关系。方法　用放射免疫分析法和分光光度法分别检测PNS患儿血、尿ET和NO水平 ,并与正常对照组进行比较 ;用直线相关分析法对血ET分别与血NO、尿ET、尿NO、血白蛋白、尿蛋白及血NO分别与尿NO、尿ET、血白蛋白、尿蛋白等进行比较。结果　PNS患儿极期血、尿ET均明显高于对照组 (P均 <0 .0 1) ,缓解期下降 ,与对照组比较无显著差异 ;血、尿NO在极期也均非常明显高于对照组 (P均 <0 .0 1) ,缓解期亦下降 ,与对照组比较无显著差异 ;血ET与血NO、尿EF、尿NO、血白蛋白、尿蛋白均无相关性 ;血NO与尿NO呈显著正相关 (r =0 .4 99,P <0 .0 5 ) ,与尿ET、血白蛋白、尿蛋白均无相关性。结论　ET。Objective To study the change of the plasma and urinary endothelin (ET) and nitric oxide (NO) in the children with primary nephritic syndrome (PNS) and their relationship.Methods The plasma and urinary ET and NO levels in the children with PNS were measured respectively by using radioimmunoassay and colorimetry in acute period and remission period and compared with each other.A linear correlation between ET and serum albumin or urinary protein, and NO and serum albumin or urinary protein was analyzed.Results The levels of plasma and urinary ET in the children with PNS were all significantly higher in acute period than in the normal group ( t = 11.905 , 9.201 , respectively, all of P< 0.01 ) and all decreased in remission period and were not different from normal group (all of P> 0.05 ).The levels of plasma and urinary NO in the children with PNS in acute period and in remission period showed the same change as those of the plasma and urinary ET.NO correlation between plasma ET and plasma NO, urinary ET, urinary NO, plasma albumin or urinary protein was found (all of P> 0.05 ).The plasma NO was positively related to urinary NO ( r= 0.499 , P < 0.05 ) and not to urinary ET, plasma albumin and urinary protein (all of P > 0.05 ).Conclusion Both ET and NO may take part in the pathogenesis of PNS.

关 键 词：原发性肾病综合征 内皮素 一氧化氮 儿童 发病机制 放射免疫法 分光光度法 

分 类 号：R692[医药卫生—泌尿科学]