正常成年人血清骨钙素含量与年龄的相关关系及其意义探讨  

Serum Osteocalcin in Normal Subjects and Relationship to Age

作　　者：王大申 尹潍[1] 王维力[1] 张鹏[1] 尹伯元[1] 张梅[2] 

机构地区：[1]天津医学院内分泌研究所 [2]天津市干部疗养院

出　　处：《天津医药》1991年第2期82-85,共4页Tianjin Medical Journal

摘　　要：为了解人类随增龄而出现的骨丢失是由于骨形成下降,还是骨吸收增加,或二者共同作用的结果,本文测定了241名健康成年人的血清骨钙素(BGP),一个骨转换的敏感指标的含量。131名年龄20～69岁的妇女,血清骨钙素随年龄线性增高(r=0.538,P<0.01)。女性在50岁后骨钙素血清含量有一明显坡蜂,从40岁年龄组的4.9±1.1ng/ml(M±SD)增至60岁年龄组的5.9±0.84ng/ml。骨形成的另一指标,血清硷性磷酸酶(AKP)亦随年龄增加,且与血清BGP 的升高相关(r=0.248 P<0.05)。110名年龄20～79岁男性,血清骨钙素亦与年龄相关(r=0.21 P<0.05),但不及女性显著。血清 AKP 无随年龄升高现象。本文研究结果提示,妇女随年龄增长骨转换增加,不支持与年龄相关的骨量减少是由于骨形成下降的观点。Because it is unclear whether age-related bone loss results from increased boneresorption or decreased bone formation or both,we measured the serum level ofosteocalcin(BGP),a specific marker for bone turnover,in 131 women,ages 20 to 69years.Serum BGP increased linealy with aging(r=0.538 P<0.01)from 4.94±1.1(mean±SD) in the 4th decade to 5.9±0.84 ng/ml in the 6th decade.Serum AKP,anindex of bone formation,also increased with age and these increases correlated withincreases in BGP (r=0.248 P<0.05)The increase of BGP level was also found in 110 men,ages 20 to 79 years.SerumBGP also correlated positively with age(r=0.21 P<0.05).These data suggestedthat overall bone turnover increased with aging,but did not support the view thatage-related bone loss resulted primarily from decrease bone formation.

关 键 词：骨钙素 血清 年龄 碱性磷酸酶 

分 类 号：R446.112[医药卫生—诊断学]