肾上腺皮质机能亢进治疗前后血清骨钙素水平  

Serum Osteocalcin Levels of Cuching's Disease Before and After Treatment

作　　者：王大申 尹潍[1] 王维力[1] 尹伯元[2] 张鹏[1] 侯秉璋[2] 胡宪蕴[2] 张梅[3] 

机构地区：[1]天津医学院附属医院内分泌科 [2]天津医学院同位素教研室 [3]天津市干部疗养院

出　　处：《天津医药》1991年第3期152-155,共4页Tianjin Medical Journal

摘　　要：本文用自己建立的放射免疫分析方法测定了12例肾上腺皮质机能亢进患者的血清骨钙素(BGP)含量。治疗前,肾上腺皮质机能亢进患者平均血清 BGP(?)±2SE 为2.5±0.5ng/ml,显著低于正常值(4.8±1.3ng/ml,P<0.01)。8例患者于手术治疗后2周复查,血清 BGP 恢复至正常水平(5.1±1.8ng/ml),本文结果提示,骨钙素测定是皮质类固醇抑制成骨细胞活性的一个敏感指标。Osteocalcin(BGP)is a Vitamin K-dependent protein that is synthesized by os-teoblasts and present in circulation.We measured serum BGP concentration inCushing's disease before and after treatment.Before treatment,serum BGP levelswere decreased in 12 patients(mean±SE=2.5±0.5ng/ml)and were significantly lowerthan those observed in normals(4.8±1.3 ng/ml,P<0.01).Serum AKP levels werein the normal range.After surgical treatment,in the 8 cured patients,BGP levelswere significantly higher than before treatment and reached the normal range(5.1±1.8ng/ml).The data suggested BGP as a sensitive marker of corticosteroid induceddepression of osteoblast activity.

关 键 词：肾上腺病 皮质机能亢进 骨钙素 

分 类 号：R586.202[医药卫生—内分泌]