胺碘酮与索他洛尔治疗心肌梗死合并心律失常的疗效比较  

Amiodarone vs sotalol in treating acute myocardial infarction associated with tachyarrhythmia

作　　者：薛兆利[1] 李明智[1] 邵军[1] 谢随民[1] 

机构地区：[1]山东菏泽医学专科学校内科教研室,菏泽274030

出　　处：《中国临床药学杂志》2002年第2期68-71,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :观察胺碘酮与索他洛尔对急性心肌梗死 (AMI)合并快速型心律失常的疗效。方法 :10 0例AMI合并快速型心律失常患者随机单盲分为 2组 ,胺碘酮组 :胺碘酮 0 2g ,tid ,有效后减至 0 2g ,po ,qd ,疗程 4wk ,随访 3a。索他洛尔组 :索他洛尔80mg ,po ,bid ,剂量随病情调整 ,疗程 4wk ,随访 3a。结果 :住院期间胺碘酮组梗死后心绞痛发生次数、应用硝酸甘油量、止痛药次数均较索他洛尔组少。经随访 3a ,胺碘酮组发生不稳定性心绞痛、再发心肌梗死、心力衰竭均较索他洛尔组少 (P <0 0 5 )。结论 :小剂量胺碘酮治疗AMI合并快速型心律失常作用可靠 ,值得应用。AIM: To investigate the efficacy of amiodarone and sotalol in treating acute myocardial infarction (AMI) associated with tachyarrythmia. METHODS: One hundred Cases of AMI with tachyarrhythmia were randomly single blind and respectively assigned into 2 groups, patients in amiodarone group were treated with amiodarone 0.2 g tid for 5 to 7 d, followed by 0.2 g,qd for 4 wk, then followed up for 3 a. Patients in sotalol group were given 80 mg, bid for 4 wk, then followed up 3 a. RESULTS: During in hospital period, the amount of attacks of post infarction angina, consumption of intravenous nitroglycerin, and time of analgesics reguired in amiodarone group decreased significantly than that of sotalol ( P <0.05), during the subsequent period of survey, the attacks of unstable angina, recurrent myocardial infarction and heart failure in amiodarone group were significantly fewer. CONCLUSION: Low dosage of amiodarone is effective in treating AMI complicated with tachyarrhythmia with mild adverse drug reactions.

关 键 词：并发症 心肌梗死 疗效比较 胺碘酮 索他洛尔 快速型心律失常 

分 类 号：R542.22[医药卫生—心血管疾病] R541.71[医药卫生—内科学]