酸枣仁皂甙A镇静和抗惊厥作用试验  

Sedative and anticonvulsant effect of jujuboside A

作　　者：封洲燕[1] 郭殿武 苏松[3] 赵辉[3] 郑筱祥[3] 

机构地区：[1]浙江大学生命科学学院,浙江杭州310027 [2]杭州民生药业公司,浙江杭州310011 [3]浙江大学生物医学工程学院,浙江杭州310027

出　　处：《浙江大学学报（医学版）》2002年第2期103-106,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：国家重点科技攻关基金资助项目 (99- 92 9- 0 4 - 0 3);浙江大学生物医学工程教育部重点实验室访问学者基金项目

摘　　要：目的 :考察酸枣仁皂甙 A(Ju A)的中枢神经系统抑制作用。方法 :利用新型抖笼测试系统 ,考察 Ju A积累剂量和单次剂量用药对小鼠自主活动所产生的镇静作用 ,同时与安定的镇静作用进行比较 ;并观察小鼠腹腔注射Ju A后对戊四氮诱发惊厥的影响。结果 :Ju A积累剂量和单次剂量均可使小鼠的活动强度显著减少 ,静息时间显著增加 ,并且作用效果比较持久、平稳 ;但 Ju A对戊四氮诱发的惊厥无对抗作用。结论 :Ju A具有中枢神经系统镇静作用 。Objective: To study the sedative effects of Jujuboside A (JuA) on the Central Nervous System of mice. Methods: Using a novel jiggle cage test, we compared the sedative effect of JuA with that of Diazepam (DZP) both with a single and cumulative dose of JuA. We also assessed the anticonvulsant effect of JuA on pentylenetetrazol (PTZ) induced seizures in mice. Results: JuA significantly decreased total activity intensity and increased the quiet state time of mice. The sedative effects of JuA were more stable and more lasting than that of DZP. However, JuA failed to resist and delay the induced seizure activity in mice. Conclusion: Though JuA has sedative effects on mice CNS, it has no anticonvulsant effect on PTZ induced seizures.

关 键 词：酸枣仁 皂甙类 抗惊厥药 酸枣仁皂甙A 镇静作用 动物实验 

分 类 号：R285.5[医药卫生—中药学]