良园枇杷膏对咳嗽反射和纤毛运动的作用  

Anti-tussive and expectorant effects of Lianguan Pipagao, a Chinese medicine

作　　者：谢强敏[1] 沈文会[1] 吴希美[1] 卞如濂[1] 

机构地区：[1]浙江大学医学院国家药品监督管理局浙江呼吸药物研究实验室,浙江杭州310031

出　　处：《浙江大学学报（医学版）》2002年第2期131-134,共4页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的 :评价良园枇杷膏对咳嗽反射抑制和对纤毛运动的增强作用。方法 :用枸橼酸引咳法和辣椒素引咳法观察枇杷膏对豚鼠和小鼠的镇咳作用 ;用小鼠气道酚红排泄法和蛙上腭纤毛运动法观察枇杷膏的祛痰作用。结果 :镇咳作用 :枇杷膏 2 .5 g/ kg和 7.5 g/ kg(ig)明显减少枸橼酸引起的豚鼠咳嗽次数 ,6 .6 g/ kg和 13.2 g/ kg(ig)明显减少辣椒素引起的小鼠咳嗽次数 ,ID50 (95 %可信限 )分别为 2 .6 4(1.12～ 6 .19) g/ kg和 11.4 0 (5 .76～ 2 2 .5 8) g/kg。祛痰作用 :枇杷膏 6 .6 g/ kg和 13.2 g/ kg(ig)明显增加小鼠气道酚红排泄量 ,ED50 (95 %可信限 )为 7.70 (4.6 2～12 .83) g/ kg,0 .11× 10 -4g/ L～ 2× 10 -4g/ L呈剂量反应 ,增加蛙上腭纤毛运动 ,EC2 5(95 %可信限 )为 1.0 7× 10 -4(0 .394～ 2 .92× 10 -4) g/ L。结论Objective: To evaluate the pharmacological effects of Liangyuan Pipagao on cough reflex and ciliary action. Liangyuan Pipagao is a compound preparation of traditional Chinese medicine. Methods: Cough was induced by aerosol citric acid in guinea pigs and aerosol capsacin in mice.Excretion function of the airway in mice was determined by phenol red method. Ciliary movement function of frog esophagus was examined by a migration method of charcoal granules. Results: Liangyuan Pipagao inhibited both the citric acid induced cough in guinea pigs and capsacin induced cough in mice.ID 50 value 2.64 g/kg (95%Cl 1.12～6.19) and 11.40 g/kg (95%Cl 5.76～22.58) respectively.Further, Liagnyuan Piapagao increased phenol red excretion in mice airways and stimulated ciliary action of frog esophagusin a dose dependent fashion.ED 50 value 7.70 g/kg (95% Cl 4.62～12.83) and EC 25 value 1.07×10 -4 (95% Cl 0.394～2.92×10 -4 ) respectively. Conclusion: Linagyuan Pipagao a traditional Chinese medicine may have anti tussive as well as expectorant actions.

关 键 词：枇杷叶膏 药理 辣椒辣素 哮喘 病因 枸橼酸 咳嗽反射 纤毛运动 中成药 

分 类 号：R285.5[医药卫生—中药学]