尼莫地平缓释片的制备及体外释药特性的评价  

Formulation and evaluation of sustained release tablets of nimodipine

作　　者：管清香[1] 林天慕[2] 张恒弼[3] 

机构地区：[1]吉林大学药学院药剂教研室,吉林长春130021 [2]第四军医大学吉林军医学院药学教研室 [3]解放军第208医院药剂科

出　　处：《吉林大学学报（医学版）》2002年第2期141-143,共3页Journal of Jilin University：Medicine Edition

摘　　要：目的 :制备高效、长效的尼莫地平缓释片。方法 :正交设计法对片剂处方进行筛选与优化。将尼莫地平固体分散体与羟丙甲基纤维素等混合 ,干法直接压制缓释片 ,测定其释药特性。结果 :缓释片体外释药符合 Higuchi方程 ( r=0 .990 8)和一级动力学 ( r=0 .9940 )。处方 4的 t50 =2 .39h且可持续释药达 1 0 h以上。HPMC、乳糖、聚乙二醇 60 0 0及甲基纤维素水平的变化对释药速率均有显著影响 ( P<0 .0 1 )。结论 :制备的缓释片具有高效。Objective: To prepare effective and long termed action nimodipine sustained release tablets. Methods: The orthogonal test was employed in the formulations. Nimodipine solid dispersion, hydroxypropylmethylcellulose (HPMC) and other excipients were mixed to prepare tablets by power compression. An optimum formulation was screened by comparing release characteristics. Results: The dissolution behavior in vitro of the nimodipine sustained release tablets followed Higuchi kinetic and first order kinetic equation. Its t 50 was 2.39 h and the release of drug was retarded over 10 h. Analysis of variance demonstrated variations of the amount of HPMC, lactose, methylcellulose and PEG6000 had significant effects on release rates ( P <0. 01). Conclusion: The effective and sustained release tablets with long term action have been prepared.

关 键 词：尼莫地平 固体分散体 体外释放度 尼莫地平缓释片 制备 

分 类 号：R972.4[医药卫生—药品] R944.4[医药卫生—药学]