B超介导纤支镜清除包裹性胸腔积液加腔内注射尿激酶的疗效  

Clearance of encapsulated pleural effusion by B ultrasonography guided fibrobronchoscopy and intrapleural urokinase infusion.

作　　者：左万里[1] 谢汝缓[1] 

机构地区：[1]广东江门市中心医院,529071

出　　处：《新医学》2002年第5期280-281,共2页Journal of New Medicine

摘　　要：目的:评估在B超介导下以纤维支气管镜(纤支镜)清除包裹性胸腔积液加腔内注射尿激酶的疗效。方法:以随机抽样方法,将已诊断为结核性包裹积液40例患者分为对照组和治疗组,两组均在常规抗结核治疗基础上,对照组(20例)予常规针刺胸腔穿刺抽液,而治疗组(20例)则在B超介导下以纤支镜清除胸腔积液后腔内注射尿激酶25OkU,观察两组患者的退热时间、胸腔积液吸收时间、住院日数、治疗后胸膜厚度和治疗前、后肺功能指标。结果:治疗组的退热时间为(4±2)日、胸腔积液吸收时间(10±3)日、住院(21±3)日均较对照组犤对应为(6±2)日、(19±4)日、(21±4)日犦短,治疗后胸膜厚度较对照组小犤(1.3±0.4)mm比(3.9±0.8)mm犦,肺功能指标(肺活量和2秒用力呼气量/用力肺活量)较对照组进步快,均为P<0.01,两组比较有统计学差异。结论:B超引导纤支镜清除包裹积液加腔内注入尿激酶治疗结核性包裹性胸腔积液有良好疗效。Objective:To study the clearance of encapsulated pleural effusion by B ultrasonography guided fibrobronchoscopy and intrapleural urokinase infusion.Methods:Forty patients with tuberculous encapsulated pleural effusion were randomly divided into two groups:control group and therapeutic group.Both groups accepted conventional anti tuberculosis treatment. Encapsulated pleural effusion was drainage by puncture in control group and by B ultrasonography guided intra pleural fibrobronchoscopy with intra pleural infusion of 250 kU urokinase in therapeutic group. The duration of fever,effusion absorption and hospitalization,depth of pleura and pulmonary function were measured before and after treatment. Results:Compared with control group,the duration of fever and effusion absorption was shortened. Pleura depth decreased and pulmonary function (VC and FEV2/FVC) were improved in therapeutic group. However,duration of hospitalization was same in both groups. Conclusion:Encapsulated pleural effusion can be effectively cleared by B ultrasonography guided fibrobronchoscopy and intrapleural urokinase infusion.

关 键 词：B超介导 包裹性胸腔积液 腔内注射 尿激酶 疗效 纤维支气管镜 肺功能 

分 类 号：R521.7[医药卫生—内科学]