可描述横向电场中外周神经兴奋的电缆方程  

A MODIFYING CABLE FUNCTION FOR REPRESENTING THE EXCITATION OF PERIPHERAL NERVES BY TRANSVERSE FIELD

作　　者：王毅[1] 沈强[1] 于辉[1] 蒋大宗[1] 

机构地区：[1]西安交通大学生物医学工程研究所,陕西西安710049

出　　处：《生物物理学报》2002年第1期44-48,共5页Acta Biophysica Sinica

基　　金：国家自然科学基金资助项目 (39900037)

摘　　要：传统的电缆方程只能用于描述纵向电场中外周神经的兴奋 ,无法描述外周神经在横向电场作用下的兴奋。基于两阶段过程模型,提出一种改进的电缆方程 ,可以描述外周神经在横向电场中的兴奋 ,其结果和Struijk的离体实验数据相吻合。The classical cable equation has been only used to represent the response of peripheral nerve to external electrical field in the direction of the nerve, and can not describe the excitation of peripheral nerve to the transverse field induced by pulse magnetic field. In this paper, a modified cable equation is obtained to represent the response of peripheral nerve to a transverse field. The simulation results demonstrate that the excitation results from net inward current along radial direction. It is in agreement with the empirical results of Struijk of the magnetic stimulation of myelinated nerve in vitro. This modified cable equation can be used to represent the response of peripheral nerve to arbitrary electric field and to improve the stimulation coil in magnetic stimulation.

关 键 词：横向电场 兴奋 外周神经 电缆方程 

分 类 号：R338.8[医药卫生—人体生理学] Q424[医药卫生—基础医学]