氚标记东莨菪碱及其标记位置的研究  

~3H-LABELLING OF SCOPOLAMINE AND THE LABELLING LOCATION

作　　者：仪明光 孟昭兴[2] 

机构地区：[1]中国原子能科学研究院同位素所 [2]北京师范大学化学系

出　　处：《同位素》1991年第4期221-225,共5页Journal of Isotopes

摘　　要：一、前言东莨菪碱(Scopolamine)是一种麻醉药物,它是中草药曼陀罗花的主要成份。氚标记东莨菪碱是用于动物组织中的吸收,分布和代谢的研究。Scopolamine is an important anaesthetic. ~3H-scopolamine was prepared by Wilzbach tritium gas-exposure method for the study of its pharmacokneties. The total radioactivity of ~3H-scopolamine was 61.8 MBq, radiochemical purity was 97%,and specific activity was 3.9 MBq/ mg. The location of ~3H-labelling was studied by calculating the superdelocalizability S_r(E) by CNDO/2 method. The calculated results agreed with experimental values by chemical dissociation method. The calculations showed that ~3H of tropic acid is 72% that of ~3H-scopolamine. As can be seen, the location of ~3H-labelling is mainly on the tropic acid.

关 键 词：氚气曝射 东莨菪碱 氚 标记 

分 类 号：R971.2[医药卫生—药品]