急性高血压引起血管重建的数值模拟  

NUMERICAL SIMULATION OF ARTERIAL REMODELING IN RESPONSE TO ACUTE HYPERTENSION

作　　者：柳兆荣[1] 徐刚[1] 覃开蓉[1] 滕忠照[1] 

机构地区：[1]复旦大学生物力学实验室,上海200433

出　　处：《力学学报》2002年第2期229-237,共9页Chinese Journal of Theoretical and Applied Mechanics

基　　金：国家自然科学基金重点项目(19732003);国家自然科学青年基金项目(19702002)资助.

摘　　要：通过建立血管重建率方程对急性高血压引起的血管零应力状态重建进行模拟．为体现高血压血管重建在时间和空间上的不均匀性，在重建率方程中引入生长因子，对零应力状态血管的重建进程进行有效控制．以６只正常大鼠腹主动脉的重建为例，对该动脉段由急性高血压引起的重建进行数值模拟．结果表明，所模拟的６只大鼠急性高血压引起的腹主动脉重建都具有相类似的重建趋势和特征，说明所提出的血管重建方法对急性高血压诱发血管重建的预测具有一定的普遍性．同时，由于在分析模型中引进反映重建非均匀性的生长因子，使得所模拟的重建进程能较好地符合急性高血压血管重建的基本生理病理特征．Studies on hypertension-induced vascular remodeling not only help understand the specific self-adaptive features of living materials, but also are of great instructive significance for the pathological research and effective prevention and treatment of hypertension. Thus, study on vascular remodeling caused by hypertension has been one of current research hotspots. In this study, remodeling rate equations were established to simulate the evolution of the arterial remodeling behavior in response to acute hypertension. The temporal variations of vascular geometric configuration and mean circumferential stress were calculated under acute hypertension condition. In order to embody the temporal and spatial nonuniformity of the arterial wall remodeling, growing factors were introduced in this paper so that the remodeling process of the zero-stress state of the artery can be controlled effectively. The numerical results, obtained respectively from the abdominal aortas of six rats, showed that the arterial wall remodeling of these different rats appeared the same remodeling trend and feature, which demonstrated that the method in this paper for simulating arterial wall remodeling in response to acute hypertension has catholicity in some degree. Due to the introduction of the growing factors in the analytical model, the simulated remodeling process was in reasonable agreement with the basic physiological and pathological features (especially during several days after the loa,d of high blood pressure) of arterial remodeling in response to acute hypertension revealed by Liu and Fung.

关 键 词：急性高血压 数值模拟 零应力状态 血管重建 重建率方程 生长因子 鼠腹主动脉 非均匀性 生理病理特征 

分 类 号：R544.1[医药卫生—心血管疾病] R318.01[医药卫生—内科学]