周围神经损伤后大鼠背根神经节细胞NMDA受体表达的可塑性改变  

Plasticity of NMDA receptor expression in rat dorsal root ganglion after peripheral nerve injury

作　　者：谭爱娟[1] 令狐清溪[2] 王瑞[1] 

机构地区：[1]山西医科大学神经生物学研究室,太原030001 [2]山西医科大学第一临床医学院口腔科

出　　处：《山西医科大学学报》2002年第2期97-98,共2页Journal of Shanxi Medical University

摘　　要：目的　观察外周神经切断后初级感觉神经元内N -甲基 -D -天冬氨酸 (NMDA)受体表达的改变。方法　采用免疫细胞化学技术显示背根节内NMDAR1(NMDAR1-LI)阳性细胞数。结果　坐骨神经切断后大鼠腰段背根节内NMDAR1的表达显著下调。结论　外周神经损伤后 ,初级感觉神经元NMDA受体发生可塑性改变 ,提示脊髓内谷氨酸递质活动的改变。Objective To observe the effect of axotomy on the expression of NMDA receptors in the primary sensory neurons of rats. Methods The numbers of NMDAR1-like immunoreactivity(-LI) cells in rat lumbar dorsal root ganglia (DRGs) were analysed using immunocytochemistry.Results The expression of NMDAR1 in lumbar DRGs was dramatically down-regulated after sciatic nerve section.Conclusion Following nerve section, NMDA receptors undergo plastic changes in their expression in DRG neurons, suggesting changes of glutamatic transmission in the spinal cord.

关 键 词：周围神经损伤 大鼠 背根神经节细胞 NMDA受体 表达 可塑性改变 

分 类 号：R651.3[医药卫生—外科学]