三羧氨基喹啉对人舌鳞癌裸鼠移植瘤的抑瘤效应研究  

The Antitumor Effect of Linomide in Treatment of Transplanted Human Squamous Cell Carcinoma of Tongue in Nude Mice

作　　者：傅其宏[1] 王青青[2] 吴求亮 余海[4] 

机构地区：[1]杭州市口腔医院,浙江杭州310006 [2]浙江大学免疫学研究所,浙江杭州310031 [3]浙江大学口腔医学研究所,浙江杭州310031 [4]浙江大学肿瘤研究所,浙江杭州310009

出　　处：《科技通报》2002年第2期122-126,共5页Bulletin of Science and Technology

摘　　要：目的　旨在观察三羧氨基喹啉 (L inomide)对人舌鳞状细胞癌裸鼠移植瘤生长的抑制效应 ,以明确 L inomide的抑瘤作用 ,为 L inomide用于人口腔鳞癌的治疗以及后续的进一步研究提供理论和实验依据 .方法　将人舌鳞癌细胞系 Tca8113接种至 BAL B/ C(nu/ nu)裸鼠 ,建立人舌癌裸鼠移植瘤模型 ,设立对照组、5 0 mg/ (kg· d)及 10 0 mg/ (kg· d) L inomide腹腔注射组 ,观察L inomide对肿瘤生长的抑制作用 .结果　与对照组相比 ,给予 Linomide治疗组的裸鼠皮下肿瘤体积明显缩小 (P<0 .0 1) ,肿瘤的生长明显受到抑制 ,10 0 mg/ (kg· d)组的瘤块体积要小于 5 0 mg/(kg· d)组的荷瘤裸鼠 (P<0 .0 1) ,说明 Linomide能抑制人舌癌裸鼠移植瘤的生长 ,且抑制程度与L inomide的剂量相关 .给予 L inomide治疗的荷瘤裸鼠其平均瘤重低于对照组 (P<0 .0 1) ,10 0mg/ (kg· d)组的荷瘤裸鼠的平均瘤重与 5 0 mg/ (kg· d)组的裸鼠比较 ,其瘤重的降低更为明显 (P<0 .0 1) .给药组裸鼠的存活时间与对照组相比明显延长 (P<0 .0 1) ,10 0 mg/ (kg· d)组的荷瘤裸鼠存活时间要长于 5 0 mg/ (kg· d)组的裸鼠 (P<0 .0 1) .结论　 L inomide对人舌鳞状细胞癌裸鼠移植瘤有明显的抑瘤效应 .Objective To investigate the antitumor effect of linomide in treatment of transplanted human squamous cell carcinoma of tongue in BALB/C(nu/nu) nude mice.Methods An animal model was established by inoculating the human squamous cell carcinoma cell line Tca 8113 into the BALB/C(nu/nu) nude mice.The mice were randomly divided into three groups and received linomide therapy, the antitumor effect of linomide was observed.Results It showed that subcutaneous tumor growth was significantly inhibited in mice treated with linomide compared with that in controls (P<0.01). The tumor volume and weight in nude mice received 100mg/(kg·d) linomide therapy decreased compared with that in nude mice treated with 50mg/(kg·d) linomide (P<0.01). And the nude mice treated with linomide survived longer compared with controls (P< 0.01). The nude mice treated with 100mg/(kg·d) linomide survived longer compared with the nude mice received 50mg/(kg·d) linomide therapy (P<0.01). Conclusion It indicated that linomide effectively inhibited the growth of human squamous carcinoma of tongue Tca8113 in nude mice in a dose-dependent manner.

关 键 词：三羟氨基喹啉 LINOMIDE 人舌鳞状细胞癌 裸鼠移植瘤 抑瘤效应 免疫调节剂 抗癌药 

分 类 号：R979.1[医药卫生—药品]