聚醚砜中空纤维膜血浆自动采集滤器分离血浆效能的研究  

Astudy on the efficiency of polyethersulfone hollow fiber membrane automatic plasma collector

作　　者：魏清荣[1] 赵长生[1] 陈永东[2] 王憬惺[2] 万昌秀[1] 乐以伦[1] 

机构地区：[1]四川大学高分子科学与工程系,四川成都610065 [2]中国医学科学院输血研究所

出　　处：《中国输血杂志》2002年第2期82-84,共3页Chinese Journal of Blood Transfusion

基　　金：国家"九五"攻关项目 (编号 :97 5 64 0 1 0 5 )

摘　　要：目的　评价聚醚砜中空纤维膜血浆采集滤器分离血浆的功能及有效性。方法　聚醚砜中空纤维膜血浆采集滤器与血浆分离机配套使用 ,采用单针方式 ,实现自动采集血浆。血浆蛋白浓度的测定采用双缩脲法。结果　①血浆采集过程中 ,膜滤器对血浆总蛋白的筛分系数 >95 % ,并且比较稳定 ;②血细胞比积增大时 ,血浆采集速度变慢 ,但血浆分离效率提高 ,Hct=0 .4 5时 ,血浆采集速度为 2 3.6ml/min ,血浆分离效率约为 5 2 % ,采集 2 0 0ml血浆约需要 2 0min ;③采集血浆多个循环后 ,血液的最大溶血率为 2 .5 %。结论　聚醚砜中空纤维膜血浆采集滤器与离心法等传统方法相比 ,采得的血浆质量较好 。Objective To evaluate the polyethersulfone(PES)hollow fiber membrane automatic plasma collector and its efficiency for separating plasma.Methods The plasma was collected by using the automated plasma collector with an innovating PES hollow fiber membrane plasma separator incorporated into a plasmapheresis device,using single needle.The concentration of total plasma protein was determined by Bio Rad method.Results 1)The sieving coefficients were over 95% during the plasma collection, and were stable.2)As the hematocrit (Hct) increased, the plasma collection rate decreased, but the plasma separation efficiency increased.At constant Hct of 0.45,the plasma filtration rate was 23.6ml/min,and the plasma separation efficiency was 52%.It took 20min to collect 200mL plasma.3)The maximum hemolysis rate after several circulation of collection was below 2.5%.Conclusion The plasma collection was satisfactorily performed, and the yield of plasma protein components was nearly the same as the plasma in whole blood.The PES membrane collector had a comparatively high efficiency of plasma separation.

关 键 词：中空纤维膜 聚醚砜 血浆采集滤器 分离效能 

分 类 号：R457[医药卫生—治疗学]