艾灸对绝经后骨质疏松症影响的实验和临床研究  

Experimental and Clinical Studies on Effect of Moxibustion on Postmenopausal Osteoporosis

作　　者：吴明霞[1] 吴炳煌[2] 刘献祥[2] 阙庆辉[1] 章志安[2] 李俐[1] 林鹉[1] 钱松涛[2] 

机构地区：[1]福建省第二人民医院,福州350003 [2]福建中医学院

出　　处：《中国针灸》2002年第5期334-336,共3页Chinese Acupuncture & Moxibustion

基　　金：福建省自然科学基金项目 (C970 49)

摘　　要：目的 :探讨艾灸治疗绝经后骨质疏松症的机理。方法 :12月龄雌性大鼠 4 2只 ,随机分为正常对照组、手术对照组、模型组、雌二醇组、艾灸组 ,采用摘除双侧卵巢法建立骨质疏松症的模型 ,造模 3个月后治疗 3个月 ,观察艾灸对骨代谢生化、性激素水平、骨小梁等指标的影响。结果 :经艾灸或雌二醇治疗后 ,U Ca/Cr、U HOP/Cr较模型组分别有所下降 ;S E2 、S BGP较模型组升高(P <0 0 5 ,P <0 0 1) ;骨小梁与髓腔的宽度比值 ,艾灸组和雌二醇组较模型组接近正常 ;2 2例骨质疏松症患者腰椎L1～L4 和股骨颈骨密度治疗后分别提高 1 32 %和 0 97%。结论 :艾灸和雌二醇二者的作用无显著差异 。Purpose To probe into mechanisms of moxibustion for treatment of postmenopausal osteoporosis. Methods Fourty two female rats aged 12 months were randomly divided into normal control group, operation control group, model group, estradiol group, moxibustion group, and osteoporosis model established by removing bilateral ovaries. Three months after establishment of the model, they were treated for 3 months and then effects of moxibustion on biochemical indexes of bone metabolism, levels of sexual hormones and bone trabecula were observed. Results After treatment with moxibustion or estradiol, U Ca/Cr, U HOP/Cr decreased, and S E 2, S BGP increased ( P <0 05, P <0 01) as compared with those in the model group, respectively; the ratio of bone trabecula and marrow cavity width approached to normal value as compared with the model group; bone density of lumbar vertebrae L 1～L 4 and femur neck in the 22 cases of osteoporosis were increased by 1 32% and 0 97%, respectively. Conclusions Moxibustion is an effective method for prevention and treatment of osteoporosis, and moxibustion and estradiol have similar action.

关 键 词：骨质疏松 绝经后 针灸疗法 艾条灸 骨密度 实验研究 临床研究 

分 类 号：R274.91[医药卫生—中西医结合] R246.2[医药卫生—中医骨伤科学]