美蓝及抑肽酶预防术后肠粘连的对比实验研究  

Experimental Study on Preventing Postoperative Intestinal Adhesions by Methylene Blue and Aprotinin

作　　者：丁敏[1] 王毓M 江素君[1] 王艳芳[1] 郑婷[1] 

机构地区：[1]杭州师范学院医学院外科教研室,杭州310012

出　　处：《中国普外基础与临床杂志》2002年第3期175-176,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨美蓝或 /和抑肽酶联合应用预防肠粘连的协同作用。方法　将 48只大白兔随机分为对照组 (A组 )、美蓝组 (B组 )、抑肽酶组 (C组 )和美蓝 +抑肽酶组 (D组 ) ,每组 12只 ,均制成腹腔粘连动物模型 ,于术后 14d均再次剖腹观察有无肠粘连及其程度。结果　A组粘连最重 ,以后依次为B组、C组 ,D组最轻。A组与B组、C组和D组比较 ,差异有非常显著性意义 (P<0 .0 1) ;D组与B组和C组比较 ,差异有显著性意义 (P<0 .0 5 )。结论　美蓝与抑肽酶均有预防术后肠粘连的作用 。Objective To investigate the synergetic effects of the combination methylene blue or/and aprotinin on preventing postoperative intestinal adhesions (POIA).Methods Fourty eight rabbits were divided into control group (group A), methylene blue group (group B), aprotinin group (group C), methylene blue+aprotinin group (group D). Each group contained 12 rabbits and established models of intestinal adhesions through laporotomy. Fourteen days after operation, the rabbits were re operated to see whether there were adhesions and the degree of adhesions. Results The adhesions of group A was the most serious, then in sequence were group B, C, group D showed very light adhesion. Group A was much more severe than B, C, D group ( P < 0.01) ; group D was very different from B, C group ( P <0.05). Conclusion Methylene blue and aprotinin have significant effects on preventing POIA and the combination of the two drugs can have a synergetic effects on POIA.

关 键 词：肠粘连 预防 美蓝 抑肽酶 动物实验 腹部手术 

分 类 号：R656[医药卫生—外科学] R619.9[医药卫生—临床医学]