胆囊胆固醇结石患者血脂和载脂蛋白水平的观察  

A Study on Serum Lipids and Apolipoprotein in Patients with Gallstone

作　　者：姚有贵[1] 李宁[1] 林琦远[1] 程南生[1] 肖路加[1] 

机构地区：[1]四川大学华西医院普外科,成都610041

出　　处：《中国普外基础与临床杂志》2002年第3期186-188,193,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨胆囊胆固醇结石患者脂质代谢变化及其在胆石成因中的地位和作用。方法　检测 161例胆囊胆固醇结石患者及 94例非结石病患者的血脂和载脂蛋白 (apolipoprotein ,Apo)。 结果　胆石组甘油三酯 (TG)和载脂蛋白CⅡ (ApoCⅡ )及载脂蛋白CⅢ (ApoCⅢ )水平明显高于对照组 ,而总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL c)及其亚组分和低密度脂蛋白胆固醇 (LDL c)明显低于对照组 (P<0 .0 1或P<0 .0 5 ) ;载脂蛋白AⅡ (ApoAⅡ )、载脂蛋白B10 0(ApoB10 0 )及载脂蛋白E(ApoE)比对照组升高 ,载脂蛋白AⅠ (ApoAⅠ )比对照组低 ,但差异无显著性意义 (P >0 .0 5 )。结论　TG、ApoCⅡ及ApoCⅢ水平的升高和TC、LDL c、HDL c及其亚组分水平的降低 ,是胆固醇结石患者脂质代谢的重要特征 。Objective To probe into disorder of plasma lipids and apolipoproteins in patients with gallstone,and their position and function in formation of gallstone. Methods Concentration of plasma lipids and apolipoproteins in 94 healthy subjects and 161 patients with gallstones was investigated. Results The gallstone group had a higher serum mean concentration of TG,Apo CⅡ,Apo CⅢ, and had a lower serum mean concentration of TC,HDL c,HDL 2 c,HDL 3 c and LDL c as compared with the control group ( P <0.01 or P <0.05). Conclusion Higher serum mean concentration of TG,Apo CⅡ,Apo CⅢ, and lower serum mean concentration of TC, HDL c, HDL 2 c, HDL 3 c and LDL c, are characteristic of lipids metabolism and important cause of formation of gallstone.

关 键 词：胆囊结石病 异常脂血症 载脂蛋白 胆囊胆固醇结石 

分 类 号：R657.4[医药卫生—外科学]