一种新型免疫细胞——NKT细胞  

NKT cell: a novel lymphoid cell lineage

作　　者：杜清友[1] 王 敏[1] 王福生[1] 

机构地区：[1]解放军302医院生物工程室,北京100039

出　　处：《免疫学杂志》2002年第3期237-239,共3页Immunological Journal

摘　　要：NKT细胞（natural killer T cells）是一类表达NK细胞表面分子标志的α/βT淋巴细胞,具有迅速分泌大量细胞因子的能力,能够对效应细胞提供早期的辅助以及在一些免疫反应中调控TH1或TH2辅助细胞的分化。NKT细胞识别由CD1d分子提呈的抗原,其作用机理既不同于NK细胞也不同于T、B淋巴细胞,在一些自身免疫性疾病,肿瘤监视及抗肿瘤方面有着非常重要的作用。Natural killer T cells (NKT) are a specialized population of α/β T cells that coexpress receptors of the natural killer (NK) lineage and have the unique potential to secret very rapidly large amounts of cytokines providing early help for effector cells and regulating the TH1 or TH2 differentiation in immune response. NKT cells are a small subset of T lymphocytes and recognize glycolipids presented by CDld mole-cules through cell recognition pathway that distincts from those of other T cell and NK cell populations. NKT cells are associated with auto-im-mune di-sease and play a crucial role in preventing or controlling malignancy.

关 键 词：NKT细胞 免疫活性 肿瘤 自身免疫性疾病 淋巴细胞 

分 类 号：R392[医药卫生—免疫学]