超临界流体快速膨胀法制备物质微粉Ⅰ.布洛芬微粉的制备  

Formation of Fine Ibuprofen Particles by Rapid Expansion of Supercritical Solution

作　　者：陈兴权[1] 于慧杰 郁威[3] 赵天生[1] 董燕敏[1] 

机构地区：[1]宁夏大学能源化工重点实验室,宁夏银川750021 [2]北京双鹤现代医药技术有限责任公司,北京100020 [3]华东理工大学化学工程研究所,上海200237

出　　处：《中国医药工业杂志》2002年第5期227-228,260,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用超临界 CO2 快速膨胀法制备了布洛芬微粉 ,考察了预膨胀压力、预膨胀温度、沉降室温度、喷嘴直径等因素对微粒直径的影响。并用Fine ibuprofen particles were prepared by rapid expansion of supercritical carbon dioxide solution. Experimental conditions such as expansion pressure, preexpansion temperature, precipitation temperature and nozzle diameter which affected fineness and uniformity of ibuprofen particles were investigated.

关 键 词：布洛芬 超临界 微粉 流体快速膨胀法 

分 类 号：R971.1[医药卫生—药品] R944.27[医药卫生—药学]