吡哌酸锌对实验性胃溃疡的保护作用及其机制  

Protective effect of Zn-pipemidate on experimental gastric ulcer and its mechanism

作　　者：刘晓丽[1] 刘春霞[1] 刘巨源[1] 杨玉亭[1] 张小毅[1] 常吉梅[2] 

机构地区：[1]新乡医学院药理教研室,新乡453003 [2]新乡医学院三附院,新乡453003

出　　处：《中国临床药理学与治疗学》2002年第2期127-129,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :研究吡哌酸锌对实验性胃溃疡的保护作用及其机制。方法 :采用大鼠幽门结扎性胃溃疡、大鼠水浸应激性胃溃疡、大鼠乙酸烧灼性胃溃疡和小鼠利血平性胃溃疡四种模型进行实验。每种模型实验动物均衡随机分为 5组 ,即羧甲基纤维素钠(CMC)阴性对照组、西米替丁 (0 .5mg·kg- 1)阳性对照组、吡哌酸锌 (0 .0 2 5、0 .0 5、0 .1g·kg- 1) 3个剂量组 (小鼠剂量加倍 ) ,灌胃给药 ,每天一次 ,连续 5d ,观察药物对实验性胃溃疡的保护作用。同时测定幽门结扎性胃溃疡各组大鼠胃液量、总酸排出量、胃蛋白酶活性和胃壁粘液量。结果 :吡哌酸锌能明显抑制 4种实验性胃溃疡的形成 ,并呈剂量依赖性。吡哌酸锌 0 .1g·kg- 1剂量组能降低胃液量 (P <0 .0 5 ) ,吡哌酸锌 0 .0 2 5、0 .0 5、0 .1g·kg- 13个剂量组均能减少总酸排出量 (P <0 .0 1) ;均能显著降低胃蛋白酶活性 (P <0 .0 1) ,并显著增加胃壁粘液量 (P<0 .0 1)。结论 :吡哌酸锌对实验性胃溃疡具有保护作用 ,其机制与增强胃粘膜保护因素、减少胃粘膜的损伤因素有关。AIM: To study protective effest of Zn-pipemidate on experimental gastric ulcer and its mechanism. METHODS: Pylous-ligated, stess-induced, acetic acid-induced and reserpine-induced gastric ulcers in rats or mice were used in experiment. Rats or mice were randomly divided into five groups including carboxymethylcellulose (CMC), cimetidine and three doses of Zn-pipemidate ( 0.025, 0.05, 0.1 g·kg -1). The drugs were given ig, once a day, for 5d. Gastric juice, out-put of pan-acid, pepsin activity and the volume of mucus gastric wall were determined in pylorus-ligated gastric ulcer in rats. RESULTS: Zn-pipemidate could inhibited the formation of all gastric ulcer models in a dose-dependent manner. All of the three doses of Zn-pipemidate groups could reduce out-put of pan-acid (P< 0.01) and pepsin activity, and increase the volume of mucus gastric wall (P< 0.01). CONCLUSION: Zn-pipemidate can protect experimental gastric ulcer. Its mechanism is related to increasing protective factors and reducing damaging factors of gastric mucosa.

关 键 词：吡哌酸锌 胃溃疡 胃酸 胃蛋白酶活性 胃壁粘液 

分 类 号：R975.6[医药卫生—药品] R573.1[医药卫生—药学]