柴胡与赤芍、醋柴胡与白芍配伍前后药效学比较研究  

Pharmacodynamics Comparison of Bupleurum Root and Red Peony Root,Vinegar-baked Bupleurum Root and Whie Peony Root between Compatibility and Single Application

作　　者：聂淑琴[1] 杨庆[1] 李兰芳[1] 黄璐琦 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2002年第3期11-14,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展规划项目 (G1 9990 5440 9)

摘　　要：目的 :观察柴胡与赤芍、醋柴胡与白芍配伍前后的药效学变化。方法 :小鼠以醋酸腹腔注射致痛、致炎观察药物的抗炎、镇痛作用 ;以酚红比色法观察胃推空和小肠排进功能 ;以胆总管引流观察大鼠的胆汁排泌功能。结果 :1 柴胡醋炙后在镇痛、利胆方面药效增强。 2 柴胡与赤芍、醋柴胡与白芍配伍后解痉作用增强。 3 柴胡与赤芍配伍 (1∶1)、醋柴胡与白芍配伍 (1∶2 )在抗炎、镇痛及胆汁排泌量上未见明显协同作用。Pharmacodynamics of compatible or single application of Bupleurum Root(BR) and Red Peony Root(RPR),Vinegar-baked Bupleurum Root(VBR)and White Peony Root(WPR)was investigated.The anti-inflammatory and analgesia action were investigated in the inflammatory and pain model induced by 1\^1% acetic acid ip in mice.The effects on gastric evacuation and intestinal movement by compatible or single application of the crude drugs were compared in mice by colorimetric method of phenol red.The promoting biliation action was detected by drained bile volume in rats.The analgesia and promoting bile excretion of VBR were stronger than BR.The antispasmodic action of compatibility BR and RPR(1∶1) or VBR and WPR(1∶2)was stronger than the single application of the drugs.The anti-inflammatory,analgesia action and promoting bile excretion effects did not show obvious difference between compatibility and single application.

关 键 词：柴胡 赤芍 白芍 配伍 药效学 

分 类 号：R285.5[医药卫生—中药学]