两对非对映体盐和两种氨基酸在二氧化碳近临界区的溶解行为  

SOLUBILITY BEHAVIOR OF FOUR DIASTEREOMERIC SALTS AND TWO AMINO ACIDS IN NEAR-CRITICAL CO_2

作　　者：高丽红[1] 刘洪来[2] 蔡水洪[3] 柴逸峰[4] 刘荔荔[4] 吴玉田[4] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]华东理工大学理学院,上海200237 [3]华东理工大学化工学院,上海200237 [4]第二军医大学药学院,上海200433

出　　处：《药学学报》2002年第5期355-358,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 (3 9770 90 4)

摘　　要：目的　考察酒石酸 麻黄碱、酒石酸 伪麻黄碱两对非对映体盐、dl 苯丙氨酸、dl 5 羟基 色氨酸在二氧化碳流体中的溶解行为。方法　用单通路法、HPCE法。结果　温度 2 5～ 5 0℃ ,压力 6 32～ 19 4 4MPa ,酒石酸 麻黄碱、酒石酸 伪麻黄碱、dl 苯丙氨酸、dl 5 羟基 色氨酸溶解度并不随二氧化碳密度增加而升高 ;在 6 32～ 7 78MPa ,溶解度随压力变化很大。结论　酒石酸 麻黄碱、酒石酸 伪麻黄碱两对非对映体盐的溶解度有差异 ,非对映体盐、dl 苯丙氨酸、dl 5 羟基 色氨酸溶解行为存在临界异常现象。AIM To establish a suitable condition for extraction of phenylalanine (Phe), 5 hydr oxytryptophan (5 OH Trp) and four diastereomeric salts, (1 R ,2 S ) ephed rine (2 S ,3 S ) tartaric acid, (1 R ,2 S ) ephedrine (2 R ,3 R ) tartaric acid, (1 S ,2 S ) pseudoephedrine (2 S ,3 S ) tartaric acid, (1 S ,2 S ) pseudoephedrine (2 R ,3 R ) tartaric acid in supercritical fluid extrac tion and to assess the solubilities of Phe, 5 OH Trp and the four diastereomer ic salts in CO 2. METHODS Single pass method and HPCE. RESULTS The solubilities of Phe, 5 OH Trp and the four diastereomeric salts in CO 2 w ere determined over temperature and pressure ranges of 25～50℃ and 6 32～34 0 3 MPa respectively. The experimental results showed that the solubilities of Phe , 5 OH Trp and the four diastereomeric salts do not increase with density of C O 2. There existed a maximum in the critical region of CO 2. CONCLUSION The dramatically high solubilities in the pressure of 6 32～7 78 MPa show a cr itical behavior, which can be explained by critical characteristic through therm odynamics analysis. The results suggest that the separation of Phe, 5 OH Trp a nd the four diastereomeric salts is more efficient in critical region of CO 2.

关 键 词：非对映体盐 DL-苯丙氨酸 dl-5-羟基-色氨酸 二氧化碳 溶解度 SFE 

分 类 号：R912[医药卫生—药学]