东菱克栓酶联合二磷酸果糖治疗急性脑梗死  

Treatment of Acute Cerebral Infarction with DF-521 in Combination with Fructose Diphosphate

作　　者：张晋 陈金和[2] 

机构地区：[1]武汉军工医院神经内科,430033 [2]武汉大学基础医学院药理学教研室,430071

出　　处：《医药导报》2002年第5期277-279,共3页Herald of Medicine

摘　　要：目的 :观察东菱克栓酶 (DF 5 2 1)联合二磷酸果糖 (FDP)治疗急性脑梗死的疗效与安全性。方法 :80例脑梗死患者随机分为治疗组与对照组各 40例。治疗组 :用DF 5 2 1,首剂 10BU ,第 3天及第 5天再分别用 5BU ,总剂量 2 0BU ,静脉滴注 ;FDP 5 0mL·d 1 ,静脉滴注 ,qd ,共用 10d。对照组 :用右旋糖酐 40注射液 5 0 0mL内加丹参注射液 2 0mL·d 1 ,静脉滴注 ,qd ,共用 14d。结果 :治疗组总有效率 92 .5 % ,显效率 70 .0 % ,对照组总有效率 70 .0 % ,显效率 37.5 %。结论 :DF 5 2 1联合FDP治疗急性脑梗死疗效显著 ,用药过程中未见出血等明显副作用。Objective:To observe the therapeutic effect and safety rate of DF 521(Defibrin) in combination with fructose diphosphate in the treatment of acute cerebral infarction. Methods:80 patients with acute cerebral infarction were randomly divided into two groups with 40 cases each in group A (the treatment group) and group B (the control group). For each patient of group A, an initial dose of 10 BU DF 521 was given by intravenous drip, followed by 5 BU every other day by the same route, until a total dose of 20 BU was reached. Concomitantly, 50 mL of fructose diphosphate were administered also by intravenous drip q.d. for 10 days. For group B, patients were given each 500 ml of dextran 40 and 20 ml of injection danshen ( Salviae Miltiorrhiza Bunge) by intravenous drip q.d. for 14 days. Results:The overall effective rate of the treatment group was 92.5% and excellent effective rate, 70.0%, while the overall effective rate of the control group was 70.0% and excellent effective rate, 37.5%. Conclusion:The therapeutic effect of DF 521 in combination with fructose 1, 6 diphosphate was dramatic in the treatment of acute cerebral infarction. No evident side effects including hemorrhage during the treatment were encountered.

关 键 词：东菱克栓酶 二磷酸果糖 梗死 脑 急性 

分 类 号：R973.2[医药卫生—药品] R743.32[医药卫生—药学]