复方丹参方对正常家兔血浆血小板粘聚性及TXA_2、PGI_2的影响  

Effects on Platelet Aggregation and Adhesion,TXA_2 and PGI_2 of Plasma of Fufangdanshenfang in Normal Rabbits

作　　者：秦彩玲[1] 刘婷[1] 张毅[1] 孙有富[1] 张淑运[1] 张伯礼[2] 

机构地区：[1]中国中医研究院中药研究所,北京100700 [2]天津中医药大学,天津300193

出　　处：《中国实验方剂学杂志》2002年第3期18-20,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展规划项目 (G1 9990 5440 3)

摘　　要：采用半体内实验方法 ,观察了复方丹参方对正常家兔血浆血小板聚集性、粘附性及TXA2 、PGI2 的影响。结果表明 :正常家兔口服复方丹参方 1 2、2 4、4 8g kg及Aspirin 4 4mg kg均显示出明显的抗ADP诱导的血小板聚集作用 ;明显抑制血小板粘附性 ;Aspirin明显降低正常家兔血浆TXA2 水平 (P <0 0 5 ) ;复方丹参方 (4 8g kg)明显升高血浆PGI2 的水平 (P <0 0 1) ;As pirin及复方丹参方各剂量组对血浆TXA2 /PGI2 比值均无明显影响。提示复方丹参方抗正常家兔血小板粘聚作用与促进 6 Ke to PGF1α的释放密切相关。Using semi-in vivo experiment method,we studied the effect of Fufangdanshwenfang on platelet aggregation and adhesion,TXA\-2 and PGI\-2 in normal rabbits.The results demonstrated that:given orally,both aspirin(4\^4mg/kg) and Fufangdanshwenfang as different dosages(1\^2,2\^4,4\^8g/kg) could markedly counteract ADP inducing platelet aggregation and inhibit platelet adhesion in normal rabbits.Moreover,aspirin could decrease the content of TXA\-2 in plasma,and Fufangdanshwenfang(4\^8g/kg)could markedly raise the content of PGI\-2 in plasma.Both aspirin(4\^4mg/kg)and Fufangdanshwenfang of different dosages had little effect on the proportion of TXA\-2 and PGI\-2 in plasma.The results suggested that the inhibition effect on platelet aggregation and adhesion of Fufangdanshwenfang was closely related to its promotion effect on the release of PGI\-2 in normal rabbits.

关 键 词：复方丹复方 血小板聚集性 粘附性 血栓素A2 前列腺素I2 

分 类 号：R285.5[医药卫生—中药学]