阿莫西林胃滞留缓释片人体内药动学研究  

Pharmacokinetics of amoxicillin gastroretentive tablets in eight healthy volunteers

作　　者：刘卫卫[1] 张纯[2] 邵元福[2] 蒋雪涛[3] 

机构地区：[1]第二军医大学南京军医学院药剂教研室,江苏南京210099 [2]第二军医大学附属长征医院药剂科,上海200003 [3]第二军医大学药学院,上海200433

出　　处：《中国药学杂志》2002年第5期360-362,共3页Chinese Pharmaceutical Journal

摘　　要：目的　研究po阿莫西林胃滞留缓释片后的药动学。方法　采用反相高效液相色谱法测定 8名健康志愿者单剂量po阿莫西林胃滞留缓释片和阿莫西林胶囊各 75 0mg后血中药物浓度 ,以 3P87药动学计算程序处理测定结果 ,计算两者的药动学参数 ,并进行统计分析。结果　两者的药动学特性符合一室模型 ,两者的消除半衰期分别为 (2 .2 9± 0 .6 5 )h与 (1.11± 0 .19)h ,达峰时间分别为 (2 .6 9± 0 .46 )h与 (1.38± 0 .13)h ,药 时曲线下面积AUC0～∞ 分别为 (2 9.86 5± 7.5 72 ) μg·h·mL-1与(38.32 5± 6 .95 1) μg·h·mL-1。结论　阿莫西林胃滞留缓释片与市售胶囊相比 ,血药峰浓度下降 ,达峰时间延长 ,生物利用度下降。OBJECTIVE: To study the pharmacokinetics of amoxicillin gastroretentive tablets. METHODS: The pharmacokinetics of amoxicillin gastrorerentive tablets and conventional capsules were studied in 8 volunteers after a single oral administration of 750 mg respectively. The concentrations of amoxicillin in plasma were measured by HPLC. RESULTS: The pharmacokinetic disposition was described by one-compartment model. The elimination half-life the test tablets and capsules were (2.29±0.65) h and (1.11±0.19) h, tmax(2.69±0.46) h and (1.38±0.13) h, AUCO∼∞(29.865±7.572) μg&middoth&middotmL-1 and (38.325±6.951) μg&middoth&middotmL-1, respectively. CONCLUSION: The results showed that the tablets had a sustained-release and long-acting effect while the bioavailability was lower than that of the conventional capsules.

关 键 词：阿莫西林 胃内滞留型缓释片 高效液相色谱法 抗生素 药代动力学 

分 类 号：R978.11[医药卫生—药品]