微小病变型肾病患者血、尿中可溶性白介素受体浓度的变化及意义  

THE CHANGE OF CONCENTRATION OF SOLUBLE INTERLEUKIN Ⅱ RECEPTORS IN PLASMA AND URINE OF PATIENTS WITH MINIMAL CHANGE NEPHROTIC SYNDROME

作　　者：王金铭[1] 刘玉夏[2] 张翠娥[1] 刘云启[2] 

机构地区：[1]滨州市人民医院,滨州市256610 [2]滨州医学院附属医院

出　　处：《滨州医学院学报》2002年第3期169-170,共2页Journal of Binzhou Medical University

摘　　要：目的 :观察可溶性白细胞介素 受体 ( s IL- 2 R)在微小病变型肾病综合征 ( MCNS)病人血浆和尿液中浓度变化 ,探讨其在免疫发病中的意义。方法 :用 ELISA分析法检测 2 3例微小病变型肾病综合征患者发病及缓解期血、尿白介素 受体 ,同时用3 H- Td R掺入法检测患者淋巴细胞增殖情况。结果 :MCNS患者在发病期血、尿 s IL- 2 Rα明显增高 ,于缓解期恢复正常。与对照组相比 ,发病期间患者尿液中增高的白介素 受体与血清浓度不成比例地异常增高。同时还发现血清可溶性白介素 受体与 T细胞体外对 PHA的增殖反应呈负相关 ,缓解期恢复正常。结论 :可溶性白介素 受体可能为血清中抑制 T细胞克隆扩增的一种因子。Objective:To observe the change of soluble interleukin 2 receptors in plasma and urine of patients with minimal change nephrotic syndrome(MCNS) and to explore its significance in pathogenesis of MCNS and abnomal immunity.Methods:Plasma and urine concentrations of sIL 2Rα were measured by ELISA in 23 MCNS patients and lymphocyte proliferative response to PHA was measured by 3 H TdR incorporation assay.Results:The plasma and urine sIL 2R concentration increased in patitents with MCNS,and the lymphocytes secreted some lymphokines in an activated state.Conclusion:sIL 2R exerted a down modulation on the IL 2 dependent proliferative response.

关 键 词：微小病变型肾病综合征 可溶性白介素Ⅱ受体 免疫学发病机制 

分 类 号：R692[医药卫生—泌尿科学] R392.7[医药卫生—外科学]